ArticleInternational journal of molecular sciences2019
Disproportionate Effect of Sub-Micron Topography on Osteoconductive Capability of Titanium.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The surface-agnostic advantage for peri-implant health: UV photofunctionalization as a positive-sum strategy for biofilm suppression and soft-tissue barrier-a systematic review with qualitative synthesis.International journal of implant dentistry · 2026Pooled it
- Bridging the missing middle in osseointegration: meso-scale topography between macro design and microroughness.International journal of implant dentistry · 2025Pooled it
- The next frontier in osseointegration: energy and speed as critical determinants and their enhancement by UV photofunctionalization.International journal of implant dentistry · 2025Article
- Treatment of large bone defects in load-bearing bone: traditional and novel bone grafts.Journal of Zhejiang University. Science. B · 2025Review
- Advancing osseointegration research: A dynamic three-dimensional (3D)Journal of dental sciences · 2025Article
- Beyond microroughness: novel approaches to navigate osteoblast activity on implant surfaces.International journal of implant dentistry · 2024Review
- Investigation of a new implant surface modification using phosphorylated pullulan.Frontiers in bioengineering and biotechnology · 2024Article
- Genome-wide transcriptional responses of osteoblasts to different titanium surface topographies.Materials today. Bio · 2023Article
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- Synergistic Enhancement of Protein Recruitment and Retention via Implant Surface Microtopography and Superhydrophilicity in a Computational Fluid Dynamics Model.International journal of molecular sciences · 2023Article
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- The Effects of a Biomimetic Hybrid Meso- and Nano-Scale Surface Topography on Blood and Protein Recruitment in a Computational Fluid Dynamics Implant Model.Biomimetics (Basel, Switzerland) · 2023Article
- A Novel High-Energy Vacuum Ultraviolet Light Photofunctionalization Approach for Decomposing Organic Molecules around Titanium.International journal of molecular sciences · 2023Article
- Article
- Cell Type-Specific Effects of Implant Provisional Restoration Materials on the Growth and Function of Human Fibroblasts and Osteoblasts.Biomimetics (Basel, Switzerland) · 2022Article
- Article
- The progress in titanium alloys used as biomedical implants: From the view of reactive oxygen species.Frontiers in bioengineering and biotechnology · 2022Review
- Surface Modification Techniques to Produce Micro/Nano-scale Topographies on Ti-Based Implant Surfaces for Improved Osseointegration.Frontiers in bioengineering and biotechnology · 2022Review
- Ultraviolet Treatment of Titanium to Enhance Adhesion and Retention of Oral Mucosa Connective Tissue and Fibroblasts.International journal of molecular sciences · 2021Article
- Corrosion Resistance and Surface Bioactivity of Ti6Al4V Alloy after Finish Turning under Ecological Cutting Conditions.Materials (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Titanium micro-scale topography offers excellent osteoconductivity and bone-implant integration. However, the biological effects of sub-micron topography are unknown. We compared osteoblastic phenotypes and in vivo bone and implant integration abilities between titanium surfaces with micro- (1-5 µm) and sub-micro-scale (0.1-0.5 µm) compartmental structures and machined titanium. The calculated average roughness was 12.5 ± 0.65, 123 ± 6.15, and 24 ± 1.2 nm for machined, micro-rough, and sub-micro-rough surfaces, respectively. In culture studies using bone marrow-derived osteoblasts, the micro-rough surface showed the lowest proliferation and fewest cells attaching during the initial stage. Calcium deposition and expression of osteoblastic genes were highest on the sub-micro-rough surface. The bone-implant integration in the Sprague-Dawley male rat femur model was the strongest on the micro-rough surface. Thus, the biological effects of titanium surfaces are not necessarily proportional to the degree of roughness in osteoblastic cultures or in vivo. Sub-micro-rough titanium ameliorates the disadvantage of micro-rough titanium by restoring cell attachment and proliferation. However, bone integration and the ability to retain cells are compromised due to its lower interfacial mechanical locking. This is the first report on sub-micron topography on a titanium surface promoting osteoblast function with minimal osseointegration.
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