ArticlePharmaceutics2019
Formulation and Characterization of Aceclofenac-Loaded Nanofiber Based Orally Dissolving Webs.
Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Preparation and Characterization of Fenofibric Acid-Loaded Electrospun Fibrous Mats.Nanomaterials (Basel, Switzerland) · 2026Article
- Electrospun PVP Nanofibrous Co-Loaded with Miconazole and Lidocaine for the Treatment of Oral Candidiasis.International journal of nanomedicine · 2026Article
- Nano-Engineered Hybridized Polymeric Framework for Chronic Wound Management.AAPS PharmSciTech · 2025Article
- Dynamic Behavior of the Glassy and Supercooled Liquid States of Aceclofenac Assessed by Dielectric and Calorimetric Techniques.Molecules (Basel, Switzerland) · 2025Article
- Evaluation of the Effect of Formulation Composition and Physicochemical Properties of Omeprazole and Bisoprolol Hemifumarate on Electrospun Nanofibers Characteristics.Nanotechnology, science and applications · 2025Article
- Article
- Optimization and Production of Aceclofenac-Loaded Microfiber Solid Dispersion by Centrifugal Spinning.Pharmaceutics · 2023Article
- Electrospun nanofibres in drug delivery: advances in controlled release strategies.RSC advances · 2023Review
- In Vitro Drug Release, Permeability, and Structural Test of Ciprofloxacin-Loaded Nanofibers.Pharmaceutics · 2021Article
- Scale-up of Electrospinning: Market Overview of Products and Devices for Pharmaceutical and Biomedical Purposes.Pharmaceutics · 2021Review
- Core-Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release.Polymers · 2020Article
- Microstructure of NiNanomaterials (Basel, Switzerland) · 2020Article
- Preparation and Characterization of Fenofibrate-Loaded PVP Electrospun Microfibrous Sheets.Pharmaceutics · 2020Article
- Recent Development of Electrospinning for Drug Delivery.Pharmaceutics · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aceclofenac-loaded poly(vinyl-pyrrolidone)-based nanofiber formulations were prepared by electrospinning to obtain drug-loaded orally disintegrating webs to enhance the solubility and dissolution rate of the poorly soluble anti-inflammatory active that belongs to the BCS Class-II. Triethanolamine-containing ternary composite of aceclofenac-poly(vinyl-pyrrolidone) nanofibers were formulated to exert the synergistic effect on the drug-dissolution improvement. The composition and the electrospinning parameters were changed to select the fibrous sample of optimum fiber characteristics. To determine the morphology of the nanofibers, scanning electron microscopy was used. Fourier transform infrared spectroscopy (FT-IR), and differential scanning calorimetry (DSC) were applied for the solid-state characterization of the samples, while the drug release profile was followed by the in vitro dissolution test. The nanofibrous formulations had diameters in the range of few hundred nanometers. FT-IR spectra and DSC thermograms indicated the amorphization of aceclofenac, which resulted in a rapid release of the active substance. The characteristics of the selected ternary fiber composition (10 mg/g aceclofenac, 1%
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