Evidence map›Paper›PMID 31426491›Full record

ArticleInternational journal of molecular sciences2019

Discovery of Novel TASK-3 Channel Blockers Using a Pharmacophore-Based Virtual Screening.

David Ramírez, Guierdy Concha, Bárbara Arévalo, Luis Prent-Peñaloza, Leandro Zúñiga, Aytug K Kiper, Susanne Rinné, Miguel Reyes-Parada, Niels Decher, Wendy González and 1 more

Abstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
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  7. 5-(Indol-2-yl)pyrazolo[3,4-Molecules (Basel, Switzerland) · 2021
    Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

David RamírezInstituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, El Llano Subercaseaux 2801-Piso 5, 8900000 Santiago, Chile.ORCID 0000-0003-0002-1189
Guierdy ConchaCentro de Investigaciones Médicas (CIM), Programa de Investigación Asociativa en Cáncer Gástrico (PIA-CG), Escuela de Medicina, Universidad de Talca, 2 Norte 685, 3460000 Talca, Chile.
Bárbara ArévaloInformática y Telecomunicaciones, Universidad Tecnológica de Chile Inacap, Sede Talca, Av. San Miguel 3496, 3460000 Talca, Chile.
Luis Prent-PeñalozaOrganic Synthesis Laboratory and Biological Activity (LSO-Act-Bio), PhD Applied Sciences, Faculty of Engineering, Institute of Chemistry of Natural Resources, Universidad de Talca, 1 Poniente No. 1141, 3460000 Talca, Chile.
Leandro ZúñigaCentro de Investigaciones Médicas (CIM), Programa de Investigación Asociativa en Cáncer Gástrico (PIA-CG), Escuela de Medicina, Universidad de Talca, 2 Norte 685, 3460000 Talca, Chile.
Aytug K KiperInstitute for Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.ORCID 0000-0003-2850-2523
Susanne RinnéInstitute for Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.
Miguel Reyes-ParadaCentro de Investigación Biomédica y Aplicada (CIBAP), Escuela de Medicina, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, Av. Libertador Bernardo O'Higgins 3677, 8900000 Santiago, Chile.ORCID 0000-0002-2376-990X
Niels DecherInstitute for Physiology and Pathophysiology, Vegetative Physiology, Philipps-University of Marburg, Deutschhausstraße 2, 35037 Marburg, Germany.ORCID 0000-0001-8892-1231
Wendy GonzálezCentro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca. 1 Poniente No. 1141, 3460000 Talca, Chile. wgonzalez@utalca.cl.ORCID 0000-0002-7535-6883
Julio CaballeroCentro de Bioinformática y Simulación Molecular (CBSM), Universidad de Talca. 1 Poniente No. 1141, 3460000 Talca, Chile. jcaballero@utalca.cl.ORCID 0000-0003-0182-1444

Funding

Deutsche Forschungsgemeinschaft DE1482-4/1Fondo de Fomento al Desarrollo Científico y Tecnológico CA13I10223Fondo Nacional de Desarrollo Científico y Tecnológico 11180604Fondo Nacional de Desarrollo Científico y Tecnológico 1170718Fondo Nacional de Desarrollo Científico y Tecnológico 1191133Iniciativa Científica Milenio MiNICAD
6 · The paper itself

Abstract

TASK-3 is a two-pore domain potassium (K

Indexed as

Drug DesignHEK293 CellsHumansMolecular Docking SimulationPotassium Channel BlockersPotassium Channels, Tandem Pore DomainKCNK9 protein, humanPotassium Channel BlockersPotassium Channels, Tandem Pore Domaindrug designlead optimizationpharmacophore-based virtual screeningTASK-3 channelTASK channels blockers

Identifiers

PMID31426491
PMCPMC6720600

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.