Evidence map›Paper›PMID 31426346›Full record

ArticleMolecules (Basel, Switzerland)2019

Synthesis of Daidzein Glycosides, α-Tocopherol Glycosides, Hesperetin Glycosides by Bioconversion and Their Potential for Anti-Allergic Functional-Foods and Cosmetics.

Yuya Fujitaka, Hiroki Hamada, Daisuke Uesugi, Atsuhito Kuboki, Kei Shimoda, Takafumi Iwaki, Yuya Kiriake, Tomohiro Saikawa

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Potential of Orally Administered Quercetin, Hesperidin, andInternational journal of molecular sciences · 2025
    Review
  3. Article
  4. Biosynthesis and Anticancer Activity of Genistein Glycoside Derivatives.Anti-cancer agents in medicinal chemistry · 2024
    Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Yuya FujitakaDepartment of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
Hiroki HamadaDepartment of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan. hamada@dls.ous.ac.jp.
Daisuke UesugiDepartment of Life Science, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
Atsuhito KubokiDepartment of Biochemistry, Faculty of Science, Okayama University of Science, 1-1 Ridai-cho, Kita-ku, Okayama 700-0005, Japan.
Kei ShimodaDepartment of Biomedical Chemistry, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan.
Takafumi IwakiDepartment of Biophysics, Faculty of Medicine, Oita University, 1-1 Hasama-machi, Oita 879-5593, Japan.
Yuya KiriakeFaculty of Medicine and Health Sciences, Yamaguchi University, 1-1-1 Minamikogushi, Ube-shi, Yamaguchi 755-8505, Japan.
Tomohiro SaikawaDepartment of Nursing, Junshin Gakuen University, 1-1-1 Tikushigaoka, Fukuoka-shi, Minami-ku, Fukuoka 815-8510, Japan.
Okayama University of Science · JPOita University · JPJunshin Gakuen University · JPYamaguchi University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Daidzein is a common isoflavone, having multiple biological effects such as anti-inflammation, anti-allergy, and anti-aging. α-Tocopherol is the tocopherol isoform with the highest vitamin E activity including anti-allergic activity and anti-cancer activity. Hesperetin is a flavone, which shows potent anti-inflammatory effects. These compounds have shortcomings, i.e., water-insolubility and poor absorption after oral administration. The glycosylation of bioactive compounds can enhance their water-solubility, physicochemical stability, intestinal absorption, and biological half-life, and improve their bio- and pharmacological properties. They were transformed by cultured

Indexed as

alpha-TocopherolAnimalsAnti-Allergic AgentsBiocatalysisCell Culture TechniquesCosmeticsFunctional FoodGlycosidesGlycosylationHesperidinHumansIsoflavonesMaleMast CellsMonophenol MonooxygenaseNicotianaalpha-TocopherolAnti-Allergic AgentsCosmeticsdaidzeinGlycosideshesperetinHesperidinIsoflavonesMonophenol Monooxygenaseanti-allergic activitydaidzeinhesperetintyrosinase inhibitory activityα-tocopherolβ-glycoside

Identifiers

PMID31426346
PMCPMC6721765
OpenAlexW2967872244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.