Evidence map›Paper›PMID 31426323›Full record

ArticleMolecules (Basel, Switzerland)2019

Evaluating the Bioactivity of a Novel Antimicrobial and Anticancer Peptide, Dermaseptin-PS4(Der-PS4), from the Skin Secretion of

Dong Chen, Xiaowei Zhou, Xi Chen, Linyuan Huang, Xinping Xi, Chengbang Ma, Mei Zhou, Lei Wang, Tianbao Chen

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
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  12. Ferritin Nanocages for Protein Delivery to Tumor Cells.Molecules (Basel, Switzerland) · 2020
    Review
  13. Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dong ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.
Xiaowei ZhouNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.
Xi ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.
Linyuan HuangNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK. huangly@cpu.edu.cn.
Xinping XiNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK. x.xi@qub.ac.uk.
Chengbang MaNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.
Mei ZhouNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.ORCID 0000-0003-2576-0252
Lei WangNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.ORCID 0000-0002-8811-8489
Tianbao ChenNatural Drug Discovery Group, School of Pharmacy, Queen's University, Belfast BT9 7BL, UK.ORCID 0000-0001-8011-9260

Funding

Shaoguan Science and Technology Planning Project 2018sn157
6 · The paper itself

Abstract

Dermaseptins belonging to a large family of cationic membrane-disruption antimicrobial peptides display extensive antibacterial and antiproliferative activities depending on a coil-to-helix transition and the specific structural parameters. Herein, a novel dermaseptin peptide named Der-PS4 was discovered from the skin secretion of the waxy monkey tree frog,

Indexed as

Amino Acid SequenceAmphibian ProteinsAnimalsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntineoplastic AgentsAnuraBiofilmsCandida albicansCell Line, TumorCell Membrane PermeabilityCloning, MolecularEndothelial CellsErythrocytesGene ExpressionGram-Negative BacteriaAmphibian ProteinsAnti-Bacterial AgentsAntimicrobial Cationic PeptidesAntineoplastic AgentsdermaseptinRecombinant Proteinsanticancer peptideantimicrobial peptidedermaseptinfrog skin secretionmolecular cloning

Identifiers

PMID31426323
PMCPMC6719146

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.