ArticleNeurobiology of aging2019
Longitudinal brain atrophy patterns and neuropsychological performance in older adults with HIV-associated neurocognitive disorder compared with early Alzheimer's disease.
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Intestinal Flora Balance Therapy Based on Probiotic Support Improves Cognitive Function and Symptoms in Patients with Alzheimer's Disease: A Systematic Review and Meta-analysis.BioMed research international · 2022Pooled it
- HIV Tat-activated microglial extracellular vesicles induce neuronal iron dysregulation and synaptodendritic injury.Cell communication and signaling : CCS · 2026Article
- Neuroimaging advances in neurocognitive disorders among HIV-infected individuals.Frontiers in neurology · 2025Review
- The prefrontal cortex, but not the medial temporal lobe, is associated with episodic memory in middle-aged persons with HIV.Journal of the International Neuropsychological Society : JINS · 2024Article
- HIV-Associated Neurocognitive Disorder (HAND) and Alzheimer's Disease Pathogenesis: Future Directions for Diagnosis and Treatment.International journal of molecular sciences · 2024Review
- Cognitive Impairment in People Living with HIV and the Impact of Mood: Results from a Cross-Sectional Study.Journal of clinical medicine · 2024Article
- Cognitive impairment in people living with HIV: consensus recommendations for a new approach.Nature reviews. Neurology · 2023Review
- Convergent and divergent oscillatory aberrations during visuospatial processing in HIV-related cognitive impairment and Alzheimer's disease.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Differential expression of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) in Alzheimer's disease and HIV-1 associated neurocognitive disorders.Scientific reports · 2023Article
- Additive cortical gray matter deficits in people living with HIV who use cocaine.Journal of neurovirology · 2023Article
- Article
- Bromodomains in Human-Immunodeficiency Virus-Associated Neurocognitive Disorders: A Model of Ferroptosis-Induced Neurodegeneration.Frontiers in neuroscience · 2022Review
- Central Nervous System Effects of COVID-19 in People with HIV Infection.Current HIV/AIDS reports · 2021Review
- Alzheimer Dementia in People Living With HIV.Neurology. Clinical practice · 2021Article
- Alzheimer Disease and HIV: Untangling the Gordian Knot.Neurology. Clinical practice · 2021Article
- Cerebrovascular Disease Correlates With Longitudinal Brain Atrophy in Virally Suppressed Older People Living With HIV.Journal of acquired immune deficiency syndromes (1999) · 2021Article
- Cognitive and motor deficits in older adults with HIV infection: Comparison with normal ageing and Parkinson's disease.Journal of neuropsychology · 2021Article
- Early prediction of putamen imaging features in HIV-associated neurocognitive impairment syndrome.BMC neurology · 2021Article
- Deep Phenotyping of HIV Neurocognitive Complications Among Individuals Residing in High-Income Countries.Current topics in behavioral neurosciences · 2021Article
- Enhancing cue salience improves aspects of naturalistic time-based prospective memory in older adults with HIV disease.Neuropsychology · 2021Article
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Authors and funding
9 authors.
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Abstract
Older HIV-infected patients are at risk for both HIV-associated neurocognitive disorder (HAND) and Alzheimer's disease. We investigated neuroimaging and neuropsychological performance of 61 virally suppressed older adults with HAND (mean (SD) age 64.3 (3.9) years), 53 demographically matched individuals with mild cognitive impairment of the Alzheimer's type (MCI-AD; 65.0 [4.8]), and 89 healthy controls (65.0 [4.3]) cross-sectionally and over 20 months. At the baseline, both disease groups exhibited lower volumes in multiple cortical and subcortical regions compared with controls. Hippocampal volume differentiated MCI-AD from HAND. Cognitively, MCI-AD performed worse on memory and language compared with HAND. Adjusted longitudinal models revealed greater diffuse brain atrophy in MCI-AD compared with controls, whereas HAND showed greater atrophy in frontal gray matter and cerebellum compared with controls. Comparing HAND with MCI-AD showed similar atrophy rates in all brain regions explored, with no significant findings. MCI-AD exhibited more pronounced language decline compared with HAND. These findings reveal the need for further work on unique cognitive phenotypes and neuroimaging signatures of HAND compared with early AD, providing preliminary clinical insight for differential diagnosis of age-related brain dysfunction in geriatric neuroHIV.
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