Trial reportBMJ (Clinical research ed.)1988
Mammographic screening and mortality from breast cancer: the Malmö mammographic screening trial.
Trial report in BMJ (Clinical research ed.), 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03279198 (Increasing Colorectal and Breast Cancer Screening in Women), which is not on this map. Cited by 172 papers, 11 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Increasing Colorectal and Breast Cancer Screening in Women
Who cites it
172 citing papers in PubMed, 11 syntheses or guidelines pooled it.
- Extending the Age Range in Mammography Screening: A Benefit-Risk Assessment from a Radiation Protection Perspective.RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin · 2026Pooled it
- Strong association between reduction of late-stage cancers and reduction of cancer-specific mortality in meta-regression of randomized screening trials across multiple cancer types.Journal of medical screening · 2024Pooled it
- Recommendations on screening for breast cancer in women aged 40-74 years who are not at increased risk for breast cancer.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2018Guideline
- Pooled it
- Meta-analysis of breast cancer mortality benefit and overdiagnosis adjusted for adherence: improving information on the effects of attending screening mammography.British journal of cancer · 2016Pooled it
- Statistical analyses in Swedish randomised trials on mammography screening and in other randomised trials on cancer screening: a systematic review.Journal of the Royal Society of Medicine · 2015Pooled it
- Is there excess mortality in women screened with mammography: a meta-analysis of non-breast cancer mortality.Trials · 2013Pooled it
- Screening for breast cancer with mammography.The Cochrane database of systematic reviews · 2013Pooled it
- Time lag to benefit after screening for breast and colorectal cancer: meta-analysis of survival data from the United States, Sweden, United Kingdom, and Denmark.BMJ (Clinical research ed.) · 2013Pooled it
- Is single reading with computer-aided detection (CAD) as good as double reading in mammography screening? A systematic review.BMC medical imaging · 2012Pooled it
- Overdiagnosis in publicly organised mammography screening programmes: systematic review of incidence trends.BMJ (Clinical research ed.) · 2009Pooled it
- Age at diagnosis in relation to survival following breast cancer: a cohort study.World journal of surgical oncology · 2015Trial
- Effect of VIA screening by primary health workers: randomized controlled study in Mumbai, India.Journal of the National Cancer Institute · 2014Trial
- Rate of over-diagnosis of breast cancer 15 years after end of Malmö mammographic screening trial: follow-up study.BMJ (Clinical research ed.) · 2006Trial
- [Introduction of a mammography screening program in Germany. Consideration of benefits and risks].Der Radiologe · 2005Trial
- Pathology characteristics that optimize outcome prediction of a breast screening trial.British journal of cancer · 2000Trial
- Mammography screening: an incremental cost effectiveness analysis of double versus single reading of mammograms.BMJ (Clinical research ed.) · 1996Trial
- Nonattendance in the Stockholm mammography screening trial: relative mortality and reasons for nonattendance.Breast cancer research and treatment · 1995Trial
- Effect of interventions on stage of mammography adoption.Journal of behavioral medicine · 1995Trial
- The Edinburgh randomised trial of breast cancer screening: results after 10 years of follow-up.British journal of cancer · 1994Trial
112 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectiveTo determine whether mortality from breast cancer could be reduced by repeated mammographic screening.
designBirth year cohorts of city population separately randomised into study and control groups.
settingScreening clinic outside main hospital. PATIENTS: Women aged over 45; 21,088 invited for screening and 21,195 in control group.
interventionsWomen in the study group were invited to attend for mammographic screening at intervals of 18-24 months. Five rounds of screening were completed. Breast cancer was treated according to stage at diagnosis. END POINT: Mortality from breast cancer. MEASUREMENTS AND MAIN
resultsAll women were followed up and classed at end point as alive without breast cancer, alive with breast cancer, dead from breast cancer, or dead from other causes. Cause of death was taken from national mortality registry and for patients with breast cancer was validated independently. Mean follow up was 8.8 years. Altogether 588 cases of breast cancer were diagnosed in the study group and 447 in the control group; 99 v 94 women died of all causes and 63 v 66 women died of breast cancer (no significant difference; relative risk 0.96 (95% confidence interval 0.68 to 1.35)). In the study group 29% more women aged less than 55 died of breast cancer (28 v 22; relative risk 1.29 (0.74 to 2.25)). More women in the study group died from breast cancer in the first seven years; after that the trend reversed, especially in women aged greater than or equal to 55 at entry. Overall, women in the study group aged greater than or equal to 55 had a 20% reduction in mortality from breast cancer (35 v 44; relative risk 0.79 (0.51 to 1.24)). OTHER
findingsIn the study group 100 (17%) cancers appeared in intervals between screenings and 107 (18%) in non-attenders; 51 of these women died from breast cancer. Cancers classed as stages II-IV comprised 33% (190/579) of cancers in the study group and 52% (231/443) in the control group.
conclusionsInvitation to mammographic screening may lead to reduced mortality from breast cancer, at least in women aged 55 or over.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.