ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2020
Influence of Striatal Dopamine, Cerebral Small Vessel Disease, and Other Risk Factors on Age-Related Parkinsonian Motor Signs.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
13 citing papers in PubMed, 26 citations in OpenAlex.
- Nigrostriatal dopaminergic integrity in relation to prefrontal cortex activity and gait performance during dual-task walking in older adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
- Correlation between cerebral small vessel disease and postural instability/gait difficulty subtype in Parkinson's disease patients.Frontiers in aging neuroscience · 2025Article
- Higher Striatal Dopamine is Related With Lower Physical Performance Fatigability in Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Association of Statins With Cerebral Atherosclerosis and Incident Parkinsonism in Older Adults.Neurology · 2022Article
- Anticholinergic Medication Use, Dopaminergic Genotype, and Recurrent Falls.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Effect of cerebral small vessel disease on cognitive impairment in Parkinson's disease: a systematic review and meta-analysis.Annals of translational medicine · 2022Article
- Cortico-striatal functional connectivity and cerebral small vessel disease: Contribution to mild Parkinsonian signs.Journal of neuroimaging : official journal of the American Society of Neuroimaging · 2022Article
- Neural correlates of slower gait in middle-aged persons with childhood-onset type 1 diabetes mellitus: The impact of accelerated brain aging.Journal of diabetes and its complications · 2022Article
- Application Value of Serum Hcy, TLR4, and CRP in the Diagnosis of Cerebral Small Vessel Disease.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Association between neuromelanin-sensitive MRI signal and psychomotor slowing in late-life depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Catechol-O-Methyltransferase Genotype, Frailty, and Gait Speed in a Biracial Cohort of Older Adults.Journal of the American Geriatrics Society · 2021Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveParkinsonian motor signs are common and disabling in older adults without Parkinson's disease (PD), but its risk factors are not completely understood. We assessed the influence of striatal dopamine levels, cerebral small vessel disease, and other factors on age-related parkinsonian motor signs in non-PD adults.
methodsStriatal dopamine transporter (DAT) binding was quantified via [11C]-CFT positron emission tomography in 87 neurologically intact adults (20-85 years, 57.47% female) with concurrent data on: Unified Parkinson's Disease Rating Scale motor (UPDRSm), white matter hyperintensities (WMH), and other risk factors (grip strength, vibratory sensitivity, cardio- and cerebro-vascular comorbidities). Sex-adjusted nonparametric models first estimated the associations of age, DAT, WMH, and other factors with UPDRSm; next, interactions of age by DAT, WMH, or other factors were tested. To quantify the influence of DAT, WMH, and other risk factors on the main association of age with UPDRSm, multivariable mediation models with bootstrapped confidence intervals (CI) were used.
resultsOlder age, lower DAT, higher WMH, and worse risk factors significantly predicted worse UPDRSm (sex-adjusted p < .04 for all). DAT, but not WMH or other factors, positively and significantly interacted with age (p = .02). DAT significantly reduced the age-UPDRSm association by 30% (results of fully adjusted mediation model: indirect effect: 0.027; bootstrapped 95% CI: 0.0007, 0.074).
conclusionsStriatal dopamine appears to influence to some extent the relationship between age and parkinsonian signs. However, much of the variance of parkinsonian signs appears unexplained. Longitudinal studies to elucidate the multifactorial causes of this common condition of older age are warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.