ArticlePLoS neglected tropical diseases2019
Ecology and seasonality of sandflies and potential reservoirs of cutaneous leishmaniasis in Ochollo, a hotspot in southern Ethiopia.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06692985 (Sentinel Surveillance of Cutaneous Leishmaniasis in Sub-Saharan Africa Based on Non-invasive Molecular Diagnostics), which is not on this map. Cited by 27 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Sentinel Surveillance of Cutaneous Leishmaniasis in Sub-Saharan Africa Based on Non-invasive Molecular Diagnostics: Mapping of Human Cases, Description of Leishamania Species Involved
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The ecoepidemiology of cutaneous leishmaniasis in Ethiopia: a systematic review and meta-analysis.Parasites & vectors · 2026Pooled it
- Leishmaniasis in deployed military populations: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2025Pooled it
- Cutaneous leishmaniasis in sub-Saharan Africa: a systematic review of Leishmania species, vectors and reservoirs.Parasites & vectors · 2024Pooled it
- In vitro evaluation of the antibacterial, antioxidant, and phytochemical investigation of Clematis simensis Fresen and Warburgia ugandensis Sprague in Ochollo, South Ethiopia.BMC complementary medicine and therapies · 2026Article
- Impact of Climatic Factors on the Incidence of Cutaneous Leishmaniasis in Essaouira, Morocco: A Decadal Analysis (2014-2023).Epidemiologia (Basel, Switzerland) · 2026Article
- Cutaneous Leishmaniasis in Tigray, Ethiopia: Clinical patterns, environmental drivers and public health implications.PLoS neglected tropical diseases · 2026Article
- Pilot study to assess the impact of feed-through insecticide on the sand fly density in an endemic area of zoonotic cutaneous leishmaniasis in Morocco.PLoS neglected tropical diseases · 2025Article
- Phlebotomine sand fly vector distribution, seasonality, blood meal sources, and infection rates in cutaneous leishmaniasis endemic areas of Northeast Ethiopia.Scientific reports · 2025Article
- Outbreak of cutaneous leishmaniasis amongst militia members in a non-endemic district under conflict in the lowlands of Somali Region caused by Leishmania tropica, Eastern Ethiopia.PLoS neglected tropical diseases · 2025Article
- Unveiling the hidden burden: Exploring the psychosocial impact of cutaneous leishmaniasis lesions and scars in southern Ethiopia.PloS one · 2025Article
- Abundance and Distribution ofTropical medicine and infectious disease · 2024Article
- Ecology and Infection Status of Sand Flies in Rural and Urban Cutaneous Leishmaniasis Endemic Areas in Northwest Ethiopia.Tropical medicine and infectious disease · 2024Article
- First report of cutaneous leishmaniasis caused by Leishmania donovani in Ethiopia.Parasites & vectors · 2023Article
- Review
- Community-based treatment of cutaneous leishmaniasis using cryotherapy and miltefosine in Southwest Ethiopia: the way forward?Frontiers in medicine · 2023Article
- Knowledge, attitude, and practice of the rural community about cutaneous leishmaniasis in Wolaita zone, southern Ethiopia.PloS one · 2023Article
- Human and animal exposure to newly discovered sand fly viruses, China.Frontiers in cellular and infection microbiology · 2023Article
- Evaluation of the CL Detect Rapid Test in Ethiopian patients suspected for Cutaneous Leishmaniasis.PLoS neglected tropical diseases · 2022Article
- Epidemiological and clinical characteristics of cutaneous leishmaniasis among patients attending at Tefera Hailu Memorial Hospital, Sekota, Northeast Ethiopia: A five-year trend analysis (2016-2020).SAGE open medicine · 2022Article
- Household knowledge, practice and treatment seeking behaviors towards cutaneous leishmaniasis in the endemic rural communities of Ganta- afeshum district, Tigrai, northern Ethiopia, 2019: a cross-sectional study.Tropical diseases, travel medicine and vaccines · 2021Article
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9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOchollo is a village in southern Ethiopia burdened with cutaneous leishmaniasis (CL), where Phlebotomus pedifer is the only vector for Leishmania aethiopica and hyraxes are confirmed reservoir hosts. A detailed description of the different players of transmission, and the ecology and seasonality of the vector needs to be established in order to accomplish efficient control programs. METHODS AND
findingsBetween March 2017 and February 2018, a monthly sandfly collection was carried out in different habitats and records of temperature and humidity were taken. Rodents and hyraxes were trapped in the dry and wet season. All samples were screened for Leishmania kinetoplast DNA (kDNA). Positive samples were further processed for determination of the Leishmania species and the species of the sandfly/small mammal that was found infected. Additionally, the species of 400 sandfly specimens from different habitats and seasons was identified. 17,190 Sergentomyia and Phlebotomus sandflies were caught and showed an overall kDNA prevalence of 2.6%, all were L. aethiopica infections only found in P. pedifer. The overall sandfly and P. pedifer abundance peaked in the dry season and was negatively correlated with the %RH. The kDNA prevalence varied over the months and was negatively correlated with the temperature. Total sandfly abundance did not differ between the sampled habitats, but P. pedifer was the distinct predominant species only in caves. Moreover, significantly more infected sandflies were found in caves. Only 1/192 rodents were kDNA positive, while 20.0% (5/25) of Heterohyrax brucei were found infected.
conclusionsThis study suggests that caves may be a source of multiplication of the infection. If an outdoor control program would be considered, it would be useful to focus on caves in the wet season, when the sandfly abundance is lowest. The captured rodent species appear not important for transmission and the contribution of hyraxes in transmission should be further investigated.
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