ArticleShock (Augusta, Ga.)2020
Inhibition of Lipolysis With Acipimox Attenuates Postburn White Adipose Tissue Browning and Hepatic Fat Infiltration.
Article in Shock (Augusta, Ga.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 26 citations in OpenAlex.
- HSF1 inhibits smooth muscle gene program to enhance white fat browning and hypermetabolism after burn injury.Science China. Life sciences · 2026Article
- Integrated serum metabolomics reveals severity-associated exploratory metabolic signatures in burn patients.Frontiers in physiology · 2026Article
- Acipimox as a potential antioxidant and neuromodulator mitigates high fat diet induced cognitive dysfunction.Scientific reports · 2025Article
- HOUSING TEMPERATURE ALTERS BURN-INDUCED HYPERMETABOLISM IN MICE.Shock (Augusta, Ga.) · 2025Article
- Altered lipid profiles in the prefrontal cortex are associated with neuroinflammation after severe burn injury.Frontiers in immunology · 2025Article
- Burns results in profound muscle protein wasting in Sprague Dawley rats that is not resolved using the lipolysis inhibitor, acipimox.PloS one · 2025Article
- The Different Shades of Thermogenic Adipose Tissue.Current obesity reports · 2024Review
- Subcutaneous white adipose tissue independently regulates burn-induced hypermetabolism via immune-adipose crosstalk.Cell reports · 2024Article
- Adipose Tissue Remodeling in Pathophysiology.Annual review of pathology · 2023Review
- Review
- Quantification of Acipimox in Plasma and Tissues by LC-MS/MS: Application to Pharmacokinetic Comparison between Normoxia and Hypoxia.Molecules (Basel, Switzerland) · 2022Article
- Angiotensin II Promotes White Adipose Tissue Browning and Lipolysis in Mice.Oxidative medicine and cellular longevity · 2022Article
- Burn-induced hypermetabolism and skeletal muscle dysfunction.American journal of physiology. Cell physiology · 2021Review
- Adipose-specific ATGL ablation reduces burn injury-induced metabolic derangements in mice.Clinical and translational medicine · 2021Article
- The impact of catecholamines on skeletal muscle following massive burns: Friend or foe?Burns : journal of the International Society for Burn Injuries · 2021Review
- Interleukin-6 blockade, a potential adjunct therapy for post-burn hypermetabolism.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- The Good, the Bad, and NLRP3-characterizing Novel Roles for the Inflammasome in Adipose-Tissue Biology and Burn Trauma.Endocrinology · 2021Article
- Burn-Induced Coagulopathies: a Comprehensive Review.Shock (Augusta, Ga.) · 2020Review
- Targeting fat browning in hypermetabolic conditions: a clinical perspective.Future science OA · 2020Article
- Adipose Tissue Metabolic Function and Dysfunction: Impact of Burn Injury.Frontiers in cell and developmental biology · 2020Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
Abstract
Extensive burn injuries promote an increase in the lipolysis of white adipose tissue (WAT), a complication that enhances postburn hypermetabolism contributing to hyperlipidemia and hepatic steatosis. The systemic increase of free fatty acids (FFAs) due to burn-induced lipolysis and subsequent organ fatty infiltration may culminate in multiple organ dysfunction and, ultimately, death. Thus, reducing WAT lipolysis to diminish the mobilization of FFAs may render an effective means to improve outcomes postburn. Here, we investigated the metabolic effects of Acipimox, a clinically approved drug that suppresses lipolysis via inhibition of hormone-sensitive lipase (HSL). Using a murine model of thermal injury, we show that specific inhibition of HSL with Acipimox effectively suppresses burn-induced lipolysis in the inguinal WAT leading to lower levels of circulating FFAs at 7 days postburn (P < 0.05). The FFA substrate shortage indirectly repressed the thermogenic activation of adipose tissue after injury, reflected by the decrease in protein expression of key browning markers, UCP-1 (P < 0.001) and PGC-1α (P < 0.01). Importantly, reduction of FFA mobilization by Acipimox significantly decreased liver weight and intracellular fat accumulation (P < 0.05), suggesting that it may also improve organ function postburn. Our data validate the pharmacological inhibition of lipolysis as a potentially powerful therapeutic strategy to counteract the detrimental metabolic effects induced by burn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.