ArticlePacing and clinical electrophysiology : PACE2019
Prevention of ventricular fibrillation through de-networking of the Purkinje system: Proof-of-Concept Paper on the Substrate Modification of the Purkinje Network.
Article in Pacing and clinical electrophysiology : PACE, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Utilizing stored implanted cardiac defibrillator electrograms to target localized fascicular denetworking in catheter ablation of ventricular fibrillation.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Mapping and ablation of ventricular fibrillation substrate.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- Novel insights into the substrate involved in maintenance of ventricular fibrillation: results from continuous multipolar mapping in a canine model.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Article
- Targeted Purkinje de-networking based on His-to-QRS onset (HiQ) map for ventricular fibrillation storm after subacute myocardial infarction.HeartRhythm case reports · 2026Article
- Radiofrequency Ablation and Right Purkinje De-Networking for Moderator Band PVC-Induced VF: Broadening the Therapeutic Landscape.JACC. Case reports · 2026Article
- Extracorporeal Membrane Oxygenation-Assisted Ablation of Extremely Refractory Purkinje Ventricular Fibrillation.JACC. Case reports · 2025Article
- Fascicular/Purkinje Tissue Colocalized With Scar in Cardiomyopathy Patients Undergoing Ventricular Fibrillation Ablation.Pacing and clinical electrophysiology : PACE · 2025Observational
- Successful catheter ablation targeting triggering premature ventricular contractions and continuous propagating activity: Suppression of ventricular fibrillation storms in ischemic cardiomyopathy.Journal of cardiology cases · 2025Article
- To reconnect or not reconnect distal Purkinje fibers, that is the question when modeling the Purkinje fiber network.Frontiers in physiology · 2025Article
- Significance of extensive ablation targeting Purkinje-muscle junction of all the left fascicles for suppressing Purkinje-related ventricular arrhythmias: A case report.HeartRhythm case reports · 2024Article
- Purkinje de-networking using a ripple map with a novel multielectrode mapping catheter for a ventricular fibrillation storm in a patient supported by an Impella device after an acute coronary syndrome.HeartRhythm case reports · 2024Article
- Successful ablation of Purkinje ectopy-triggered ventricular fibrillation storm in a patient with orthotopic heart transplantation and severe SARS-CoV-2 pneumonia: a case report.European heart journal. Case reports · 2024Article
- Catheter ablation in patients with ventricular fibrillation by purkinje de-networking.Frontiers in cardiovascular medicine · 2022Article
- Prevention of ventricular fibrillation through de-networking of the Purkinje system: Proof-of-Concept Paper on the Substrate Modification of the Purkinje Network.Pacing and clinical electrophysiology : PACE · 2019Article
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSudden cardiac death from ventricular fibrillation (VF) remains a major health problem worldwide. Currently, there are limited treatment options available to patients who suffer from episodes of VF. Because Purkinje fibers have been implicated as a source of initiation of VF, we are presenting the first paper of a series highlighting the promising results of substrate modulation through "De-Networking" of the Purkinje system preventing VF in patients without an alternative ablation strategy. METHODS AND
resultsWe studied 10 consecutive patients (two female) all but one implanted with an ICD with documented VF or fast polymorphic Ventricular tachycardia (VT) (five patients without history of structural heart disease, two with ischemic cardiomyopathy, one with hypertrophic obstructive cardiomyopathy, one with dilated cardiomyopathy, and one with aortic valve disease). After 3D electroanatomical mapping, the left bundle branch (LBB) and left ventricular Purkinje potentials were annotated creating a virtual triangle with the apex formed by the distal LBB and the base by the most distal Purkinje potentials. Linear radiofrequency catheter ablation at the base of the triangle was performed, followed by ablation within the virtual triangle sparing the LBB and both fascicles ("de-networking"). All patients were treated without complications. During 1-year follow-up, only 2/10(20%) patients experienced recurrence in form of a single episode of polymorphic VT/VF.
conclusionCatheter ablation of VF through "de-networking" of the Purkinje system in patients without overt arrhythmia substrate or trigger appears safe and effective and will require further study in a larger patient cohort.
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