Evidence map›Paper›PMID 31424182›Full record

Trial reportCNS neuroscience & therapeutics2019

Effect of single-session transcranial direct current stimulation on cognition in Parkinson's disease.

Chi-Ieong Lau, Mu-N Liu, Kae-Chwen Chang, Anna Chang, Chyi-Huey Bai, Ching-Shiang Tseng, Vincent Walsh, Han-Cheng Wang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in CNS neuroscience & therapeutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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  9. Clinical neurophysiology in the treatment of movement disorders: IFCN handbook chapter.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Chi-Ieong LauDementia Center, Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.ORCID 0000-0003-0699-2234
Mu-N LiuInstitute of Brain Science, National Yang-Ming University, Taipei, Taiwan.
Kae-Chwen ChangDepartment of Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Anna ChangDepartment of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Chyi-Huey BaiDepartment of Public Health, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Ching-Shiang TsengDepartment of Rehabilitation, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.
Vincent WalshApplied Cognitive Neuroscience Group, Institute of Cognitive Neuroscience, University College London, London, UK.
Han-Cheng WangDepartment of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsNonmotor symptoms (NMS) such as cognitive impairment and impulse-control disorders in Parkinson's disease (PD) remain a therapeutic challenge. Transcranial direct current stimulation (tDCS) has emerged as a promising alternative, although its immediate effects on NMS have been less well defined. In this randomized, sham-controlled, crossover study, we aimed to explore the single-session tDCS effects on cognitive performance in PD.

methodsTen nondemented patients with PD completed two sessions in counterbalanced order, receiving 20 minutes of either 2 mA anodal or sham tDCS over the left dorsolateral prefrontal cortex (DLPFC). During stimulation, they performed the visual working memory and go/no-go tasks. Performance of the tasks was compared between the two conditions.

resultsSingle-session anodal tDCS over the left DLPFC did not significantly improve cognitive tasks in PD compared with sham (P > .05).

conclusionSingle-session tDCS is ineffective in improving visual working memory and inhibitory control in PD. Further research may worth exploring alternative tDCS parameters, ideally with repeated sessions and concomitant training.

Indexed as

AgedCognitionCognitive DysfunctionCross-Over StudiesFemaleHumansMaleMemory, Short-TermMiddle AgedParkinson DiseasePhotic StimulationTranscranial Direct Current StimulationTreatment Outcomeinhibitory controlmemoryParkinson's diseasetDCS

Identifiers

PMID31424182
PMCPMC6834682

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.