Evidence map›Paper›PMID 31423982›Full record

ReviewDeutsches Arzteblatt international2019

Toxoplasmosis in Germany.

Uwe Pleyer, Uwe Gross, Dirk Schlüter, Henrik Wilking, Frank Seeber

Open access · greenAbstract readReview
In one paragraph

Review in Deutsches Arzteblatt international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 1 pooled it
4.1field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Seroprevalence ofInternational journal of pediatrics · 2026
    Article
  5. Evolution ofJournal of parasitology research · 2026
    Review
  6. Frontiers in psychiatry · 2026
    Article
  7. Review
  8. Anti-toxoplasma effect ofOpen veterinary journal · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Parasitological examination results of zoo animals in Germany between 2012 and 2022.International journal for parasitology. Parasites and wildlife · 2024
    Article
  14. Seroepidemiological study on coinfection of toxoplasmosis and active tuberculosis in Northern Iran: a case control study.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2024
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Uwe PleyerDepartment of Ophthalmology, Charité Campus Virchow, University Faculty of Medicine, Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health; Institute of Medical Microbiology and German Reference Laboratory for Toxoplasma Infection, Faculty of Medicine University of Göttingen; Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School (MHH); Unit 35: Gastrointestinal Infections, Zoonoses and Tropical Infections, Robert Koch Institute, Berlin; Unit 16: Mycotic and parasitic agents and mycobacteria, Robert Koch Institute, Berlin.
Uwe Gross
Dirk Schlüter
Henrik Wilking
Frank Seeber
Charité - Universitätsmedizin Berlin · DEInstitute of Medical Microbiology and Hygiene · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWith approximately 30% of the world population infected, Toxoplasma gondii is one of the most widespread pathogenic parasites in both humans and animals and a major problem for health economics in many countries.

methodsThis review is based on the findings of individual studies, meta-analyses, and Cochrane Reviews retrieved by a selective literature survey of the Medline and Google Scholar databases.

resultsCurrent data indicate a high rate of Toxoplasma gondii infection in Germany, ranging from 20% to 77% depending on age (95% confidence interval for 18- to 29-year-olds [17.0; 23.1]; for 70- to 79-year-olds [72.7; 80.5]). Male sex, caring for a cat, and a body mass index of 30 or more are independent risk factors for seroconversion. Postnatally acquired (food-related) infec- tion is predominant, but maternal-to-fetal transmission still plays an important role. While most infections are asymptomatic, congenital toxoplasmosis and reactivated Toxoplasma encephalitis in immunosuppressed persons (transplant recipients and others) are sources of considerable morbidity. Toxoplasma gondii infection of the retina is the most common cause of infectious uveitis in Germany. The diagnosis and treatment of this type of parasitic infection are particular to the specific organs involved in the individual patient.

conclusionDesirable steps for the near future include development of an effective treatment for the cystic stage and identifica- tion of biomarkers to assess the risk of reactivation and predict the disease course.

Indexed as

ToxoplasmaToxoplasmosisToxoplasmosis, CongenitalAdultAnimalsCatsGermanyHumansInfectious Disease Transmission, VerticalMaleYoung Adult

Identifiers

PMID31423982
PMCPMC6706837
OpenAlexW2952307351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.