Evidence map›Paper›PMID 31423969›Full record

ArticleEmerging infectious diseases2019

Comparison of Serologic Assays for Middle East Respiratory Syndrome Coronavirus.

Ruth Harvey, Giada Mattiuzzo, Mark Hassall, Andrea Sieberg, Marcel A Müller, Christian Drosten, Peter Rigsby, Christopher J Oxenford, study participants

Open access · diamondAbstract readComparative Study
In one paragraph

Article in Emerging infectious diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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  9. International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Ruth Harvey
Giada Mattiuzzo
Mark Hassall
Andrea Sieberg
Marcel A Müller
Christian Drosten
Peter Rigsby
Christopher J Oxenford
study participants
World Health Organization - Lyon Office · FRCharité - Universitätsmedizin Berlin · DENational Institute for Biological Standards and Control · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Middle East respiratory syndrome coronavirus (MERS-CoV) was detected in humans in 2012. Since then, sporadic outbreaks with primary transmission through dromedary camels to humans and outbreaks in healthcare settings have shown that MERS-CoV continues to pose a threat to human health. Several serologic assays for MERS-CoV have been developed globally. We describe a collaborative study to investigate the comparability of serologic assays for MERS-CoV and assess any benefit associated with the introduction of a standard reference reagent for MERS-CoV serology. Our study findings indicate that, when possible, laboratories should use a testing algorithm including >2 tests to ensure correct diagnosis of MERS-CoV. We also demonstrate that the use of a reference reagent greatly improves the agreement between assays, enabling more consistent and therefore more meaningful comparisons between results.

Indexed as

Middle East Respiratory Syndrome CoronavirusAntibodies, ViralCoronavirus InfectionsEnzyme-Linked Immunosorbent AssayFluorescent Antibody TechniqueHumansNeutralization TestsOligonucleotide Array Sequence AnalysisReference StandardsReproducibility of ResultsSensitivity and SpecificitySerologic TestsAntibodies, ViralantibodiesdiagnosticsMERS-CoVMiddle East respiratory syndrome coronavirusOmanSaudi ArabiaserologySouth Koreastandardviruses

Identifiers

PMID31423969
PMCPMC6759245
OpenAlexW2967919296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.