Evidence map›Paper›PMID 31423807›Full record

ArticleCell transplantation2019

Exosomes from Bone Marrow Mesenchymal Stem Cells Inhibit Neuronal Apoptosis and Promote Motor Function Recovery via the Wnt/β-catenin Signaling Pathway.

Ci Li, Guangjun Jiao, Wenliang Wu, Hongliang Wang, Shanwu Ren, Lu Zhang, Hongming Zhou, Haichun Liu, Yunzhen Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
78citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

78 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  13. Rewiring the Spine-Cutting-Edge Stem Cell Therapies for Spinal Cord Repair.International journal of molecular sciences · 2025
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18 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ci LiDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Guangjun JiaoDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Wenliang WuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Hongliang WangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Shanwu RenDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Lu ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Hongming ZhouDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Haichun LiuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Yunzhen ChenDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, Shandong, China.ORCID 0000-0001-8447-9001

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Severe spinal cord injury (SCI) is caused by external mechanical injury, resulting in unrecoverable neurological injury. Recent studies have shown that exosomes derived from bone marrow mesenchymal stem cells (BMSCs-Exos) might be valuable paracrine molecules in the treatment of SCI. In this study, we designed SCI models in vivo and in vitro and then investigated the possible mechanism of successful repair by BMSCs-Exos. In vivo, we established one Sham group and two SCI model groups. The Basso, Beattie, Bresnahan (BBB) scores showed that BMSCs-Exos could effectively promote the recovery of spinal cord function. The results of the Nissl staining, immunohistochemistry, and TUNEL/NeuN/DAPI double staining showed that BMSCs-Exos inhibited neuronal apoptosis. Western blot analysis showed that the protein expression level of Bcl-2 was significantly increased in the BMSCs-Exos group compared with the PBS group, while the protein expression levels of Bax, cleaved caspase-3, and cleaved caspase-9 were significantly decreased. The results of western bolt and qRT-PCR demonstrated that BMSCs-Exos could activate the Wnt/β-catenin signaling pathway effectively. In vitro, we found that inhibition of the Wnt/β-catenin signaling pathway could promote neuronal apoptosis following lipopolysaccharide (LPS) induction. These results demonstrated that BMSCs-Exos may be a promising therapeutic for SCI by activating the Wnt/β-catenin signaling pathway.

Indexed as

AnimalsApoptosisbcl-2-Associated X ProteinCaspasesCells, CulturedExosomesLipopolysaccharidesLocomotionMaleMesenchymal Stem CellsNeuronsProto-Oncogene Proteins c-bcl-2RatsRats, WistarRecovery of FunctionSpinal Cord InjuriesBax protein, ratbcl-2-Associated X ProteinBcl2 protein, ratCaspasesLipopolysaccharidesProto-Oncogene Proteins c-bcl-2apoptosisexosomesspinal cord injuryWnt/β-catenin signaling pathway

Identifiers

PMID31423807
PMCPMC6802144

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.