Evidence map›Paper›PMID 31423732›Full record

ArticleFEBS open bio2019

Development of a general logistic model for disease risk prediction using multiple SNPs.

Cheng Long, Guanting Lv, Xinmiao Fu

Abstract read
In one paragraph

Article in FEBS open bio, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Heliyon · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Cheng LongWest China Hospital of Sichuan University, Chengdu, Sichuan, China.
Guanting LvBeijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China.
Xinmiao FuProvincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, College of Life Sciences, Fujian Normal University, Fuzhou, Fujian, China.ORCID 0000-0003-3361-6904

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human diseases are usually linked to multiloci genetic alterations, including single-nucleotide polymorphisms (SNPs). Methods to use these SNPs for disease risk prediction (DRP) are of clinical interest. DRP algorithms explored by commercial companies to date have tended to be complex and led to controversial prediction results. Here, we present a general approach for establishing a logistic model-based DRP algorithm, in which multiple SNP risk factors from different publications are directly used. In particular, the coefficient β of each SNP is set as the natural logarithm of the reported odds ratio, and the constant coefficient β

Indexed as

AlgorithmsLogistic ModelsChinaFemaleHumansLung NeoplasmsMalePolymorphism, Single NucleotideRisk Factorsdisease risk predictionGWASslogistic regressionpersonalized medicineprecise medicineSNP

Identifiers

PMID31423732
PMCPMC6823278

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.