Evidence map›Paper›PMID 31423727›Full record

ArticleJournal of the International AIDS Society2019

Mortality from suicide among people living with HIV and the general Swiss population: 1988-2017.

Yann Ruffieux, Liis Lemsalu, Karoline Aebi-Popp, Alexandra Calmy, Matthias Cavassini, Christoph A Fux, Huldrych F Günthard, Catia Marzolini, Alexandra Scherrer, Pietro Vernazza and 3 more

Abstract read
In one paragraph

Article in Journal of the International AIDS Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Article
  7. Article
  8. Pandemics and Suicide Risk: Lessons From COVID and Its Predecessors.The Journal of nervous and mental disease · 2022
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yann RuffieuxInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.
Liis LemsaluDepartment of Drug and Infectious Diseases Epidemiology, National Institute for Health Development, Tallinn, Estonia.
Karoline Aebi-PoppDivision of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
Alexandra CalmyDivision of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.ORCID 0000-0002-1137-6826
Matthias CavassiniDivision of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0003-0933-7833
Christoph A FuxDepartment of Infectious Diseases and Hospital Hygiene, Kantonsspital Aarau, Aarau, Switzerland.
Huldrych F GünthardDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Catia MarzoliniDivision of Infectious Diseases and Hospital Epidemiology, Departments of Medicine and Clinical Research, University Hospital Basel, Basel, Switzerland.
Alexandra ScherrerDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
Pietro VernazzaDepartment of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St Gallen, St Gallen, Switzerland.
Olivia KeiserInstitute of Global Health, University of Geneva, Geneva, Switzerland.
Matthias EggerInstitute of Social and Preventive Medicine (ISPM), University of Bern, Bern, Switzerland.ORCID 0000-0001-7462-5132
Swiss HIV Cohort Study and the Swiss National Cohort

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionIn many countries, mortality due to suicide is higher among people living with HIV than in the general population. We aimed to analyse trends in suicide mortality before and after the introduction of triple combination antiretroviral therapy (cART), and to identify risk factors associated with death from suicide in Switzerland.

methodsWe analysed data from the Swiss HIV Cohort Study from the pre-cART (1988-1995), earlier cART (1996-2008) and later cART (2009-2017) eras. We used multivariable Cox regression to assess risk factors for death due to suicide in the ART era and computed standardized mortality ratios (SMRs) to compare mortality rates due to suicide among persons living with HIV with the general population living in Switzerland, using data from the Swiss National Cohort. RESULTS AND DISCUSSION: We included 20,136 persons living with HIV, of whom 204 (1.0%) died by suicide. In men, SMRs for suicide declined from 12.9 (95% CI 10.4-16.0) in the pre-cART era to 2.4 (95% CI 1.2-5.1) in the earlier cART and 3.1 (95% CI 2.3-4.3) in the later cART era. In women, the corresponding ratios declined from 14.2 (95% CI 7.9-25.7) to 10.2 (3.8-27.1) and to 3.3 (95% CI 1.5-7.4). Factors associated with death due to suicide included gender (adjusted hazard ratio 0.58 (95% CI 0.38-0.87) comparing women with men), nationality (1.95 (95% CI 1.34-2.83) comparing Swiss with other), Centers for Disease Control and Prevention clinical stage (0.33 (95% CI 0.24-0.46) comparing stage A with C), transmission group (2.64 (95% CI 1.71-4.09) for injection drug use and 2.10 (95% CI 1.36-3.24) for sex between men compared to other), and mental health (2.32 (95% CI 1.71-3.14) for a history of psychiatric treatment vs. no history). There was no association with age.

conclusionsSuicide rates have decreased substantially among people living with HIV in the last three decades but have remained about three times higher than in the general population since the introduction of cART. Continued emphasis on suicide prevention among men and women living with HIV is important.

Indexed as

SuicideAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveCohort StudiesFemaleHIV InfectionsHumansMaleMiddle AgedRisk FactorsSwitzerlandAnti-Retroviral Agentscomparative studyHIVintravenous drug useSMRsuicideSwitzerland

Identifiers

PMID31423727
PMCPMC6698675

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.