Evidence map›Paper›PMID 31423637›Full record

ArticleMagnetic resonance in medicine2020

Sensitivity of quantitative relaxometry and susceptibility mapping to microscopic iron distribution.

Timothy J Colgan, Gesine Knobloch, Scott B Reeder, Diego Hernando

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. The crosstalk between iron metabolism and immune tolerance in autoimmunity.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Review
  3. Article
  4. Article
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  12. Neuroimaging, Urinary, and Plasma Biomarkers of Treatment Response in Huntington's Disease: Preclinical Evidence with the p75Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2021
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Timothy J ColganDepartment of Radiology, University of Wisconsin, Madison, Wisconsin.ORCID 0000-0002-4400-7525
Gesine KnoblochDepartment of Radiology, University of Wisconsin, Madison, Wisconsin.ORCID 0000-0002-9594-7680
Scott B ReederDepartment of Radiology, University of Wisconsin, Madison, Wisconsin.ORCID 0000-0003-4728-8171
Diego HernandoDepartment of Radiology, University of Wisconsin, Madison, Wisconsin.ORCID 0000-0002-0016-0317

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Confounder-Corrected Quantitative MRI Biomarkers of HepaticR01DK100651 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI REEDER, SCOTT B. · 2014 to 2017
$2.7M
MRI-based Quantitative Susceptibility Mapping of Hepatic Iron OverloadR01DK117354 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI HERNANDO, DIEGO · 2018 to 2021
$2.3M
Quantitative Magnetic Resonance Imaging PhantomsR44EB025729 · NIBIB · CALIMETRIX, LLC · PI BRITTAIN, JEAN H., HERNANDO, DIEGO · 2019 to 2020
$1.5M
Quantitative Magnetic Resonance Imaging PhantomsR41EB025729 · NIBIB · CALIMETRIX, LLC · PI HERNANDO, DIEGO · 2018 to 2018
$239k
NCI NIH HHS T32 CA009206NIBIB NIH HHS R41 EB025729NIBIB NIH HHS R44 EB025729NIDDK NIH HHS R01 DK100651NIDDK NIH HHS R01 DK117354
6 · The paper itself

Abstract

purposeDetermine the impact of the microscopic spatial distribution of iron on relaxometry and susceptibility-based estimates of iron concentration.

methodsMonte Carlo simulations and in vitro experiments of erythrocytes were used to create different microscopic distributions of iron. Measuring iron with intact erythrocyte cells created a heterogeneous distribution of iron, whereas lysing erythrocytes was used to create a homogeneous distribution of iron. Multi-echo spin echo and spoiled gradient echo acquisitions were then used to estimate relaxation parameters (

resultsSimulations demonstrate that

conclusions

Indexed as

Magnetic Resonance ImagingMicroscopyAlgorithmsBrainComputer SimulationContrast MediaErythrocyte MembraneErythrocytesFerric CompoundsHeartHumansImage Processing, Computer-AssistedIronIron OverloadLiverMonte Carlo MethodContrast MediaFerric Compoundsferric oxideIronchemical shift-encoded MRIiron quantificationquantitative susceptibility mapping

Identifiers

PMID31423637
PMCPMC7041893

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.