ArticleMagnetic resonance in medicine2020
More than BOLD: Dual-spin populations create functional contrast.
Article in Magnetic resonance in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Factors Associated with Blood Glucose Fluctuations in Patients with Type 2 Diabetes: A Retrospective Observational Study Using Continuous Glucose Monitoring.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Characterization of the blood oxygen level dependent hemodynamic response function in human subcortical regions with high spatiotemporal resolution.Frontiers in neuroscience · 2022Article
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Authors and funding
6 authors.
Funding
Abstract
purposeFunctional MRI contrast has generally been associated with changes in transverse relaxivity caused by blood oxygen concentration, the so-called blood oxygen level dependent contrast. However, this interpretation of fMRI contrast has been called into question by several recent experiments at high spatial resolution. Experiments were conducted to examine contrast dependencies that cannot be explained only by differences in relaxivity in a single-spin population.
methodsMeasurements of functional signal and contrast were obtained in human early visual cortex during a high-contrast visual stimulation over a large range of TEs and for several flip angles. Small voxels (1.5 mm) were used to restrict the measurements to cortical gray matter in early visual areas identified using retinotopic mapping procedures.
resultsMeasurements were consistent with models that include 2 spin populations. The dominant population has a relatively short transverse lifetime that is strongly modulated by activation. However, functional contrast is also affected by volume changes between this short-lived population and the longer-lived population.
conclusionSome of the previously observed "nonclassical" behaviors of functional contrast can be explained by these interacting dual-spin populations.
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