ArticleNature metabolism2019
Increased β-cell proliferation before immune cell invasion prevents progression of type 1 diabetes.
Abstract read
In one paragraph
Article in Nature metabolism, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
6.6field-weighted citation impact, top 3% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Whether or Not the Effects ofNutrients · 2020Pooled it
- Murine and Humanized Mouse Models in Autoimmune Disease Research and Therapeutics Development.Biology · 2026Review
- March5-mediated Trim28 degradation preserves islet β-cell function in mice.Nature communications · 2025Article
- State-dependent central synaptic regulation by GLP-1 is essential for energy homeostasis.Nature metabolism · 2025Article
- RSPO1, a potent inducer of pancreatic β cell neogenesis.Cell reports. Medicine · 2025Article
- Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis.Communications biology · 2024Article
- Redox regulation of mNature cell biology · 2024Article
- Development, regeneration, and physiological expansion of functional β-cells: Cellular sources and regulators.Frontiers in cell and developmental biology · 2024Review
- Beta cell dedifferentiation in type 1 diabetes: sacrificing function for survival?Frontiers in endocrinology · 2024Article
- Ghrelin deletion and conditional ghrelin cell ablation increase pancreatic islet size in mice.The Journal of clinical investigation · 2023Article
- Islet autoimmunity in human type 1 diabetes: initiation and progression from the perspective of the beta cell.Diabetologia · 2023Review
- Talin-1 inhibits Smurf1-mediated Stat3 degradation to modulate β-cell proliferation and mass in mice.Cell death & disease · 2023Article
- The potential of β-cell growth promotion, continued.Journal of diabetes · 2023Article
- Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake.Cell & bioscience · 2022Article
- The β-Cell in Type 1 Diabetes Pathogenesis: A Victim of Circumstances or an Instigator of Tragic Events?Diabetes · 2022Review
- Pancreatic β-Cell Development and Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Role of Polyamines and Hypusine in β Cells and Diabetes Pathogenesis.Metabolites · 2022Review
- Interactions between islets and regulatory immune cells in health and type 1 diabetes.Diabetologia · 2021Review
- High-fat diet prevents the development of autoimmune diabetes in NOD mice.Diabetes, obesity & metabolism · 2021Article
- Mitochondrial-encoded MOTS-c prevents pancreatic islet destruction in autoimmune diabetes.Cell reports · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 2 countries.
Ercument DiriceIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Sevim KahramanIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Dario F De JesusIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Abdelfattah El OuaamariIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Giorgio BasileIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Rocky L BakerDepartment of Immunology, School of Medicine, University of Colorado, Aurora, CO, USA.
Burcu YigitDivision of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
Paul D PiehowskiBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Mi-Jeong KimSection for Immunobiology, Joslin Diabetes Center, Boston, MA, USA.
Alexander J DwyerUniversity of Minnesota, Center for Immunology, Department of Medicine, Minneapolis, MN, USA.
Raymond W S NgIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Cornelia SchusterSection for Immunobiology, Joslin Diabetes Center, Boston, MA, USA.
Heidrun VetheIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Tijana MartinovUniversity of Minnesota, Center for Immunology, Department of Medicine, Minneapolis, MN, USA.
Yuki IshikawaSection for Immunobiology, Joslin Diabetes Center, Boston, MA, USA.
Adrian Kee Keong TeoIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Richard D SmithBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Jiang HuIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Kathryn HaskinsDepartment of Immunology, School of Medicine, University of Colorado, Aurora, CO, USA.
Thomas SerwoldSection for Immunobiology, Joslin Diabetes Center, Boston, MA, USA.
Wei-Jun QianBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA, USA.
Brian T FifeUniversity of Minnesota, Center for Immunology, Department of Medicine, Minneapolis, MN, USA.
Stephan KisslerSection for Immunobiology, Joslin Diabetes Center, Boston, MA, USA.
Rohit N KulkarniIslet Cell and Regenerative Biology, Joslin Diabetes Center, Boston, MA, USA.
Brigham and Women's Hospital · USJoslin Diabetes Center · USPacific Northwest National Laboratory · USUniversity of Minnesota · USUniversity of Colorado Anschutz Medical Campus · USBeth Israel Deaconess Medical Center · US
Funding
SPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 1986 to 2026
$50.5MEquipment Supplement Request for a Research Resource for Ultra-sensitive High Throughput ProteomicsP41GM103493 · NIGMS · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI SMITH, RICHARD D · 2012 to 2022
$22.6MRole of IGF-1 and Insulin Receptors Beta-Cell SurvivalR01DK067536 · NIDDK · JOSLIN DIABETES CENTER · PI ROHIT N. KULKARNI · 2004 to 2026
$8.0MHybrid Peptides as Autoantigens for Diabetogenic CD4 T CellsR01DK081166 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HASKINS, KATHRYN M, JAMES, EDDIE A · 2011 to 2024
$7.3MRegulatory Networks and Biomarkers of Beta-cell Dysfunction and ApoptosisUC4DK104167 · NIDDK · BATTELLE PACIFIC NORTHWEST LABORATORIES · PI KULKARNI, ROHIT N., MATHEWS, CLAYTON E · 2014 to 2016
$2.7MRole of SerpinB1 in beta cell growthR01DK103215 · NIDDK · JOSLIN DIABETES CENTER · PI KULKARNI, ROHIT N. · 2014 to 2018
$2.6MMechanisms of immune tolerance in autoimmune diabetesR01AI106791 · NIAID · UNIVERSITY OF MINNESOTA · PI FIFE, BRIAN T · 2014 to 2018
$1.9MT cells reactive to Hybrid Insulin Peptides (HIPs) as biomarkers in autoimmune diabetesR21AI133059 · NIAID · UNIVERSITY OF COLORADO DENVER · PI BAKER, ROCKY LEE · 2018 to 2019
$428kNIAID NIH HHS R01 AI106791NIAID NIH HHS R21 AI133059NIDDK NIH HHS P30 DK036836NIDDK NIH HHS R01 DK067536NIDDK NIH HHS R01 DK081166NIDDK NIH HHS R01 DK103215NIDDK NIH HHS UC4 DK104167NIGMS NIH HHS P41 GM103493
Abstract
Type 1 diabetes (T1D) is characterized by pancreatic islet infiltration by autoreactive immune cells and a near-total loss of β-cells
Indexed as
Cell ProliferationAnimalsDiabetes Mellitus, Type 1Disease ProgressionHumansImmune SystemInsulin-Secreting CellsMice
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.