Evidence map›Paper›PMID 31423303›Full record

ArticleBiomedical reports2019

Non-invasive measurement of hemodynamic response to postural stress using inert gas rebreathing.

Ksenija Stach, Julia D Michels, Christina Doesch, Joachim Brade, Theano Papavassiliu, Martin Borggrefe, Ibrahim Akin, Joachim Saur, Frederik Trinkmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ksenija StachFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.
Julia D MichelsFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.
Christina DoeschFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.
Joachim BradeDepartment of Medical Statistics, University Medical Centre Mannheim, Medical Faculty Mannheim, University of Heidelberg, D-68167 Mannheim, Germany.
Theano PapavassiliuFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.
Martin BorggrefeFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.
Ibrahim AkinFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.
Joachim SaurFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.
Frederik TrinkmannFirst Department of Medicine, University Medical Center Mannheim, Faculty of Medicine, University of Heidelberg, European Center for AngioScience, D-68167 Mannheim, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In postural stress, an increased preload volume leads to higher stroke volume (SV) according to the Frank-Starling law of the heart. The present study aimed to evaluate the hemodynamic response to postural stress using non-invasive inert gas rebreathing (IGR) in patients with normal as well as impaired left ventricular function. Hemodynamic measurements were performed in 91 patients undergoing cardiac magnetic resonance imaging (CMR). Mean cardiac output and SV determined by IGR were 4.4±1.3 l/min and 60±19 ml in the upright position, which increased significantly to 5.0±1.2 l/min and 75±23 ml in the supine position (P<0.01). Left ventricular systolic function was normal [ejection fraction (EF) ≥55%] in 42 patients as determined by CMR. In 21 patients, EF was mildly abnormal (45-54%), in 16 patients moderately abnormal (30-44%) and in 12 patients severely abnormal (<30%). An overall trend for a lower percentage change in SV (%ΔSV) was indicated with increasing impairment of ejection fraction. In patients with abnormal EF in comparison to those with normal EF, the %ΔSV was significantly lower (13% vs. 22%; P=0.03). Non-invasive measurement of cardiac function using IGR during postural changes may be feasible and detected significant difference in %ΔSV in patients with normal and impaired EF according to the Frank-Starling law of the heart. Several clinical scenarios including cases of heart rhythm disturbances or pulmonary or congenital heart disease are worthy of further investigation.

Indexed as

cardiac outputheart failureinert gas rebreathingpostural stressstroke volume

Identifiers

PMID31423303
PMCPMC6684938

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.