Evidence map›Paper›PMID 31423194›Full record

ArticleOncology letters2019

Demethylation of SOCS1 mediates its abnormally high expression in ovarian cancer.

Xuejiao Li, Chuimiao Kong, Yuchun Fan, Jia Liu, Weiyuan Lu, Caiyun Meng, Aimei Li, Aixia Zhai, Bingqing Yan, Wuqi Song and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology letters, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Xuejiao LiDepartment of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin, Heilongjiang 150081, P.R. China.
Chuimiao KongDepartment of Gynecology Endoscopy Section, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Yuchun FanDepartment of Gynecology Endoscopy Section, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Jia LiuDepartment of Gynecology Endoscopy Section, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Weiyuan LuDepartment of Gynecology Endoscopy Section, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Caiyun MengDepartment of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin, Heilongjiang 150081, P.R. China.
Aimei LiDepartment of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin, Heilongjiang 150081, P.R. China.
Aixia ZhaiDepartment of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin, Heilongjiang 150081, P.R. China.
Bingqing YanDepartment of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin, Heilongjiang 150081, P.R. China.
Wuqi SongDepartment of Microbiology, Harbin Medical University, Wu Lien-Teh Institute, The Heilongjiang Key Laboratory of Immunity and Infection, The Key Laboratory of Pathogenic Biology, Heilongjiang Higher Education Institutions, Harbin, Heilongjiang 150081, P.R. China.
Xu HanDepartment of Gynecology Endoscopy Section, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China.
Harbin Medical University · CNHeilongjiang University · CNFirst Affiliated Hospital of Harbin Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The present study aimed to investigate the association between methylation and the high expression of the suppressor of cytokine signaling 1 (SOCS1) in ovarian cancer by detecting the methylation rate and the degree of expression. The present study investigated the expression of SOCS1 mRNA and SOCS1 protein in ovarian cancer and normal ovary tissues using reverse transcription-quantitative polymerase chain reaction (PCR) and immunohistochemistry, and the methylation status of the CpG islands of SOCS1 mRNA in ovarian cancer tissue were examined using a methylation-specific PCR. The expression levels of SOCS1 mRNA in ovarian cancer specimens were significantly increased compared with that in the normal ovary tissues (P=0.0215). Consistent with this, the expression levels of SOCS1 protein in ovarian cancer specimens were significantly increased, while the methylation rate of SOCS1 mRNA was significantly decreased compared with that in the normal ovary tissues. Therefore, it may be concluded that the low methylation rate of SOCS1 mRNA in ovarian cancer increased the expression of SOCS1 mRNA, which may serve a role in the development of ovarian cancer.

Indexed as

gene expressionmethylationovarian cancerreverse transcription-quantitative polymerase chain reactionsuppressor of cytokine signaling 1

Identifiers

PMID31423194
PMCPMC6607400
OpenAlexW2954350313

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.