Representative subsampling of sedimenting blood.

Bhargav Rallabandi, Janine K Nunes, Antonio Perazzo, Sergey Gershtein, Howard A Stone

Abstract read

In one paragraph

Article in Proceedings. Mathematical, physical, and engineering sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Red Blood Cell Sedimentation Index Using Shear Stress of Blood Flow in Microfluidic Channel.Biosensors · 2022
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Bhargav RallabandiDepartment of Mechanical Engineering, University of California, Riverside, CA 92521, USA.ORCID 0000-0002-7733-8742

Janine K NunesDepartment of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-1742-2934

Antonio PerazzoDepartment of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.ORCID 0000-0002-0380-4245

Sergey GershteinAbbott Point of Care, Princeton, NJ 08540, USA.

Howard A StoneDepartment of Mechanical and Aerospace Engineering, Princeton University, Princeton, NJ 08544, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is often necessary to extract a small amount of a suspension, such as blood, from a larger sample of the same material for the purposes of diagnostics, testing or imaging. A practical challenge is that the cells in blood sediment noticeably on the time scale of a few minutes, making a representative subsampling of the original sample challenging. Guided by experimental data, we develop a Kynch sedimentation model to discuss design considerations that ensure a representative subsampling of blood, from a container of constant cross-sectional area, for the entire range of physiologically relevant hematocrit over a specified time of interest. Additionally, we show that this design may be modified to exploit the sedimentation and perform subsampling to achieve either higher or lower hematocrit relative to that of the original sample. Thus, our method provides a simple tool to either concentrate or dilute small quantities of blood or other sedimenting suspensions.

Indexed as

bloodcomplex fluidsKrieger–DoughertyKynchsedimentation

Identifiers

PMID31423102

DOI10.1098/rspa.2019.0223

PMCPMC6694302

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.