Evidence map›Paper›PMID 31422912›Full record

ArticleCell stem cell2019

Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.

Hannah T Stuart, Giuliano G Stirparo, Tim Lohoff, Lawrence E Bates, Masaki Kinoshita, Chee Y Lim, Elsa J Sousa, Katsiaryna Maskalenka, Aliaksandra Radzisheuskaya, Andrew A Malcolm and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. BRD8 Guards the Pluripotent State by Sensing and Maintaining Histone Acetylation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  5. Article
  6. Article
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  8. bioRxiv : the preprint server for biology · 2024
    Article
  9. Pathway analysis through mutual information.Bioinformatics (Oxford, England) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Hannah T StuartWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Giuliano G StirparoWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Tim LohoffWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Lawrence E BatesWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Masaki KinoshitaWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Chee Y LimWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Haematology and Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Elsa J SousaWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Katsiaryna MaskalenkaWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Aliaksandra RadzisheuskayaWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Andrew A MalcolmWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Mariana R P AlvesWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Rebecca L LloydWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK.
Sonia NestorowaWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Haematology and Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
Peter HumphreysWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
William MansfieldWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Wolf ReikWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Babraham Institute and Wellcome Sanger Institute, Cambridge, UK.
Paul BertoneWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Jennifer NicholsWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Berthold GöttgensWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Haematology and Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK.
José C R SilvaWellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK; Department of Biochemistry, University of Cambridge, Cambridge, UK. Electronic address: jcs64@cam.ac.uk.

Funding

Cancer Research UKMedical Research Council 1233706Medical Research Council 1509287Medical Research Council MC_PC_12009Medical Research Council MR/R017735/1Wellcome Trust 101861
6 · The paper itself

Abstract

Understanding how cell identity transitions occur and whether there are multiple paths between the same beginning and end states are questions of wide interest. Here we show that acquisition of naive pluripotency can follow transcriptionally and mechanistically distinct routes. Starting from post-implantation epiblast stem cells (EpiSCs), one route advances through a mesodermal state prior to naive pluripotency induction, whereas another transiently resembles the early inner cell mass and correspondingly gains greater developmental potency. These routes utilize distinct signaling networks and transcription factors but subsequently converge on the same naive endpoint, showing surprising flexibility in mechanisms underlying identity transitions and suggesting that naive pluripotency is a multidimensional attractor state. These route differences are reconciled by precise expression of Oct4 as a unifying, essential, and sufficient feature. We propose that fine-tuned regulation of this "transition factor" underpins multidimensional access to naive pluripotency, offering a conceptual framework for understanding cell identity transitions.

Indexed as

AnimalsBlastocyst Inner Cell MassCell DifferentiationCell LineCell PlasticityCellular ReprogrammingFemaleGene Expression Regulation, DevelopmentalGene Regulatory NetworksGerm LayersMiceMice, Inbred C57BLOctamer Transcription Factor-3Pluripotent Stem CellsSignal TransductionOctamer Transcription Factor-3Pou5f1 protein, mousecell identity transitionspluripotencyreprogrammingsignalingtranscriptional networks

Identifiers

PMID31422912
PMCPMC6731995

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.