ArticleStem cell reports2019
Generation of a Purified iPSC-Derived Smooth Muscle-like Population for Cell Sheet Engineering.
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Article in Stem cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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23citing papers in PubMed
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Who cites it
23 citing papers in PubMed.
- Advances in Biomaterial-Based Cardiac Organoids Engineering for Modeling Development and Congenital Heart Defects.ACS applied bio materials · 2026Review
- Organ-Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis.bioRxiv : the preprint server for biology · 2026Article
- Immunogenicity of induced pluripotent stem cell-derived smooth muscle cells results from a reduction in the expression of indoleamine 2,3 dioxygenase (IDO-1).Regenerative medicine · 2026Article
- Review
- Maternal dietary fibre intake results in sex-specific single-cell molecular changes in the heart of the offspring.Clinical science (London, England : 1979) · 2025Article
- A Unified Map of Airway Interactions: Secretome and Mechanotransduction Loops from Development to Disease.Advances in respiratory medicine · 2025Review
- Novel Directly Reprogrammed Smooth Muscle Cells Promote Vascular Regeneration as Microvascular Mural Cells.Circulation · 2025Article
- Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models.Stem cell reports · 2025Review
- Stem-Cell-Based Small-Diameter Blood Vessels with 3D Printing.Small science · 2024Article
- Reporter Alleles in hiPSCs: Visual Cues on Development and Disease.International journal of molecular sciences · 2024Review
- Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- The challenges and prospects of smooth muscle tissue engineering.Regenerative medicine · 2024Review
- Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme.Nature communications · 2023Article
- Large-scale engineering of hiPSC-derived nephron sheets and cryopreservation of their progenitors.Stem cell research & therapy · 2022Article
- A three-dimensional culture system for generating cardiac spheroids composed of cardiomyocytes, endothelial cells, smooth-muscle cells, and cardiac fibroblasts derived from human induced-pluripotent stem cells.Frontiers in bioengineering and biotechnology · 2022Article
- Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography.Micromachines · 2021Article
- Human Induced Pluripotent Stem Cell-Derived Vascular Cells: Recent Progress and Future Directions.Journal of cardiovascular development and disease · 2021Review
- Mechanical properties of cell sheets and spheroids: the link between single cells and complex tissues.Biophysical reviews · 2021Review
- Review
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Authors and funding
5 authors.
George KwongCenter for Regenerative Medicine, Boston University and Boston Medical Center, 670 Albany Street, 2(nd) Floor, Boston, MA 02118, USA; Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA.
Hector A MarquezCenter for Regenerative Medicine, Boston University and Boston Medical Center, 670 Albany Street, 2(nd) Floor, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA.
Chian YangCenter for Regenerative Medicine, Boston University and Boston Medical Center, 670 Albany Street, 2(nd) Floor, Boston, MA 02118, USA; Department of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA.
Joyce Y WongDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston, MA 02215, USA. Electronic address: jywong@bu.edu.
Darrell N KottonCenter for Regenerative Medicine, Boston University and Boston Medical Center, 670 Albany Street, 2(nd) Floor, Boston, MA 02118, USA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, 72 East Concord Street, Boston, MA 02118, USA. Electronic address: dkotton@bu.edu.
Funding
Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3MBIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3MDerivation of Transplantable Lung Epithelial Progenitors from iPS CellsR01HL095993 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2009 to 2026
$7.5MA National iPS Cell Network with Deep Phenotyping for Translational ResearchU01TR001810 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GILAD, YOAV, KOTTON, DARRELL N. · 2016 to 2020
$4.4MVascular Cell Phenotype on Physiologically-relevant Bioengineered SubstrataR01HL072900 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI WONG, JOYCE Y · 2003 to 2011
$3.6MTraining Program in Cardiovascular Biology: Pre-DoctoralT32HL007969 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI RAVID, KATYA · 2003 to 2019
$3.2MA National Resource for Lung disease-specific iPS cellsR24HL123828 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N., MOSTOSLAVSKY, GUSTAVO · 2014 to 2018
$2.7MEpigenenomic and transcriptomic networks in normal and defective lung developmentR01HL128172 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2015 to 2018
$2.2MiPSC Modeling of the Role of NKX2-1 in Human Lung Development and DiseaseR01HL122442 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI KOTTON, DARRELL N. · 2014 to 2017
$1.6MDouble-Reporter Induced Pluripotent Stem Cells for Vascular Cell Sheet EngineeringF31HL128085 · NHLBI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI KWONG, GEORGE · 2015 to 2016
$63kNCATS NIH HHS U01 TR001810NCATS NIH HHS UL1 TR001430NHLBI NIH HHS F31 HL128085NHLBI NIH HHS R01 HL072900NHLBI NIH HHS R01 HL095993NHLBI NIH HHS R01 HL122442NHLBI NIH HHS R01 HL128172NHLBI NIH HHS R24 HL123828NHLBI NIH HHS T32 HL007035NHLBI NIH HHS T32 HL007969
Abstract
Induced pluripotent stem cells (iPSCs) provide a potential source for the derivation of smooth muscle cells (SMCs); however, current approaches are limited by the production of heterogeneous cell types and a paucity of tools or markers for tracking and purifying candidate SMCs. Here, we develop murine and human iPSC lines carrying fluorochrome reporters (Acta2
Indexed as
Tissue EngineeringActinsAnimalsAortaCell DifferentiationCell LineageFemaleGene ExpressionHumansInduced Pluripotent Stem CellsMiceMice, Inbred C57BLMice, TransgenicMyocytes, Smooth MuscleMyosin Heavy ChainsPrincipal Component AnalysisACTA2 protein, humanActinsmyosin 11, mouseMyosin Heavy Chainscell sheetsdirected differentiationfluorochrome reportersinduced pluripotent stem cellssmooth muscle cells
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.