Evidence map›Paper›PMID 31422881›Full record

ArticleCurrent biology : CB2019

Non-Crh Glutamatergic Neurons in Barrington's Nucleus Control Micturition via Glutamatergic Afferents from the Midbrain and Hypothalamus.

Anne M J Verstegen, Nataliya Klymko, Lin Zhu, John C Mathai, Reina Kobayashi, Anne Venner, Rachel A Ross, Veronique G VanderHorst, Elda Arrigoni, Joel C Geerling and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 70 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Urogenital dysfunction in neurological diseases.Nature reviews. Neurology · 2026
    Review
  5. From bladder to brain: How you know when it's time to go.Current opinion in neurobiology · 2025
    Review
  6. Diurnal regulation of urinary behavior and gene expression in aged mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. NEURAL CONTROL OF SOMATIC FUNCTION: THE NEW FRONTIER OF PHYSIOLOGY AND PATHOPHYSIOLOGY.Transactions of the American Clinical and Climatological Association · 2024
    Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Neural circuit control of innate behaviors.Science China. Life sciences · 2022
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Anne M J VerstegenDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA. Electronic address: aversteg@bidmc.harvard.edu.
Nataliya KlymkoDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Lin ZhuDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
John C MathaiDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Reina KobayashiDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Anne VennerDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Rachel A RossDivision of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Veronique G VanderHorstDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Elda ArrigoniDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Joel C GeerlingDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Mark L ZeidelDivision of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Ave., Boston, MA 02215, USA.
Harvard University · USBeth Israel Deaconess Medical Center · US

Funding

Fostering Research Mentorship & Training during Psychiatry Residency SupplementR25MH094612 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FAVA, MAURIZIO, GREENFIELD, SHELLY F. · 2011 to 2022
$2.3M
Mapping brainstem control of continenceR01DK113030 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI ZEIDEL, MARK L. · 2017 to 2021
$1.9M
Dissecting a novel prefrontal cortical pathway regulating feeding behaviorK08DK118201 · NIDDK · MCLEAN HOSPITAL · PI ROSS, RACHEL A · 2019 to 2022
$963k
ProjectP20DK103086 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI MATHAI, JOHN · 2014 to 2015
$694k
NIDDK NIH HHS K08 DK118201NIDDK NIH HHS P20 DK103086NIDDK NIH HHS R01 DK113030NIMH NIH HHS R25 MH094612
6 · The paper itself

Abstract

Lower urinary tract symptoms (LUTS) are exceptionally common and debilitating, and they are likely caused or exacerbated by dysfunction of neural circuits controlling bladder function. An incomplete understanding of neural control of bladder function limits our ability to clinically address LUTS. Barrington's nucleus (Bar) provides descending control of bladder and sphincter function, and its glutamatergic neurons expressing corticotropin releasing hormone (Bar

Indexed as

AnimalsBarrington's NucleusCorticotropin-Releasing HormoneFemaleHypothalamusMaleMesencephalonMiceNeuronsNeurons, AfferentUrinationCorticotropin-Releasing HormoneBarrington's nucleusbladdercorticotropin-releasing hormonecystometrylateral hypothalamic areamicturitionmicturition video thermographyneural circuitsneuroscienceperiaqueductal gray

Identifiers

PMID31422881
PMCPMC6736713
OpenAlexW2968099720

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.