ArticleImmunity2019
A Thpok-Directed Transcriptional Circuitry Promotes Bcl6 and Maf Expression to Orchestrate T Follicular Helper Differentiation.
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Article in Immunity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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34citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
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Who cites it
34 citing papers in PubMed, 42 citations in OpenAlex.
- Super-enhancer profiling reveals ThPOK/ZBTB7B, a CD4Cellular and molecular life sciences : CMLS · 2025Article
- KMT2D coordinates antiviral CD4Cell reports · 2025Article
- Aberrant T follicular helper cells generated by TNature immunology · 2025Article
- Transcription factor c-Maf: a checkpoint that programs autoimmunity.Frontiers in immunology · 2025Review
- Deciphering Alzheimer's disease transcriptomics: exploration and validation of core genes in tau and Aβ pathological models toward novel therapeutic targets.Frontiers in aging neuroscience · 2025Article
- Advances and challenges in identifying precursors of memory CD4Frontiers in immunology · 2025Review
- Evolving understanding of autoimmune mechanisms and new therapeutic strategies of autoimmune disorders.Signal transduction and targeted therapy · 2024Review
- Maf expression in B cells restricts reactive plasmablast and germinal center B cell expansion.Nature communications · 2024Article
- PRMT5 Promotes T follicular helper Cell Differentiation and Germinal Center Responses during Influenza Virus Infection.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Key Functions of the Transcription Factor BCL6 During T-Cell Differentiation.Advances in experimental medicine and biology · 2024Review
- Spatiotemporal resolution of germinal center Tfh cell differentiation and divergence from central memory CD4Nature communications · 2023Article
- Imbalance of follicular regulatory T (Tfr) cells/follicular helper T (Tfh) cells in adult patients with primary immune thrombocytopenia.Experimental biology and medicine (Maywood, N.J.) · 2023Article
- Lung tissue-resident memory T cells: the gatekeeper to respiratory viral (re)-infection.Current opinion in immunology · 2023Review
- Generation of Retrogenic Mice to Investigate T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Genetic Strategies to Study T Cell Development.Methods in molecular biology (Clifton, N.J.) · 2023Article
- A CD4eLife · 2022Article
- NuRD complex recruitment to Thpok mediates CD4Science immunology · 2022Article
- The Aryl Hydrocarbon Receptor Modulates T Follicular Helper Cell Responses to Influenza Virus Infection in Mice.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- The transcription factor LRF promotes integrin β7 expression by and gut homing of CD8ααNature immunology · 2022Article
- Naive and memory CD4iScience · 2022Article
Corrections and comments
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Authors and funding
17 authors at 6 institutions in 1 country.
Melanie S VacchioLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Thomas CiucciLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Yayi GaoLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Masashi WatanabeExperimental Immunology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Mariah Balmaceno-CrissLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Mitchell T McGintyLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Allan HuangLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Qi XiaoLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Cameron McConkeyLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Yongmei ZhaoCenter for Cancer Research Sequencing Facility, Advanced Technology Research Facility, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Jyoti ShettyCenter for Cancer Research Sequencing Facility, Advanced Technology Research Facility, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Bao TranCenter for Cancer Research Sequencing Facility, Advanced Technology Research Facility, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Marion PepperDepartment of Immunology, University of Washington, Seattle, WA, USA.
Golnaz VahediDepartment of Genetics, University of Pennsylvania, Philadelphia, PA, USA.
Marc K JenkinsCenter for Immunology, Department of Microbiology and Immunology, University of Minnesota, Minneapolis, MN, USA.
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD, USA.
Rémy BosselutLaboratory of Immune Cell Biology, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA. Electronic address: bosselur@nih.gov.
National Cancer Institute · USCenter for Cancer Research · USNational Institute of Neurological Disorders and Stroke · USUniversity of Minnesota Medical Center · USUniversity of Pennsylvania · USUniversity of Washington · US
Funding
Pathogenesis of viral meningitisZIANS003112 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI MCGAVERN, DORIAN · 2009 to 2025
$33.6MThe differentiation and function of CD4+ Th2 cells during allergen-induced asthmaR01AI108626 · NIAID · UNIVERSITY OF WASHINGTON · PI PEPPER, MARION · 2014 to 2018
$2.4MCritical role of TCF-1 on the epigenetic identity of memory T cellsR01HL145754 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI VAHEDI, GOLNAZ · 2019 to 2023
$2.3MIntramural NIH HHS Z99 CA999999NHLBI NIH HHS R01 HL145754NIAID NIH HHS R01 AI108626
Abstract
The generation of high-affinity neutralizing antibodies, the objective of most vaccine strategies, occurs in B cells within germinal centers (GCs) and requires rate-limiting "help" from follicular helper CD4
Indexed as
AnimalsAntibodies, NeutralizingB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationFemaleGene Expression RegulationGerminal CenterLymphocyte ActivationMiceMice, Inbred C57BLProto-Oncogene Proteins c-bcl-6Proto-Oncogene Proteins c-mafT-Lymphocytes, Helper-InducerTranscription FactorsTranscription, GeneticAntibodies, NeutralizingBcl6 protein, mouseMaf protein, mouseProto-Oncogene Proteins c-bcl-6Proto-Oncogene Proteins c-mafTranscription FactorsZbtb7b protein, mouseBcl6CD4 T cellsfollicular helper T cellsgerminal center reactionMafThpok
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.