ArticleBiological psychiatry2019
Dorsal Amygdala Neurotrophin-3 Decreases Anxious Temperament in Primates.
Article in Biological psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 38 citations in OpenAlex.
- Experimental change in temperament: Conversion of the low exploratory phenotype into highly explorative by overexpression of GDNF in the rat striatum.Molecular psychiatry · 2026Article
- Neurotrophin-3 produced by motor neurons non-cell autonomously regulate the development of pre-motor interneurons in the developing spinal cord.bioRxiv : the preprint server for biology · 2026Article
- Study of the Pharmacological Activity Spectrum of the New Original NT-3 Mimetic Dipeptide GTS-302.Doklady. Biochemistry and biophysics · 2025Article
- An Honest Reckoning With the Amygdala and Mental Illness.The American journal of psychiatry · 2024Review
- The amygdala NT3-TrkC pathway underlies inter-individual differences in fear extinction and related synaptic plasticity.Molecular psychiatry · 2024Article
- Understanding the heterogeneity of anxiety using a translational neuroscience approach.Cognitive, affective & behavioral neuroscience · 2024Review
- Current and Future Approaches to Pediatric Anxiety Disorder Treatment.The American journal of psychiatry · 2024Review
- Gene expression in the primate orbitofrontal cortex related to anxious temperament.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- TrkC Intracellular Signalling in the Brain Fear Network During the Formation of a Contextual Fear Memory.Molecular neurobiology · 2023Article
- Hippocampal RNA sequencing in mice selectively bred for high and low activity.Genes, brain, and behavior · 2023Article
- Real-time trajectory guide tracking for intraoperative MRI-guided neurosurgery.Magnetic resonance in medicine · 2023Article
- DREADD-mediated amygdala activation is sufficient to induce anxiety-like responses in young nonhuman primates.Current research in neurobiology · 2023Article
- Evaluating depression- and anxiety-like behaviors in non-human primates.Frontiers in behavioral neuroscience · 2022Review
- Evidence in primates supporting the use of chemogenetics for the treatment of human refractory neuropsychiatric disorders.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Clozapine is my favorite color: Chemogenetic modulation of anxiety-related behavior in primates.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- Infant inhibited temperament in primates predicts adult behavior, is heritable, and is associated with anxiety-relevant genetic variation.Molecular psychiatry · 2021Article
- Combining brain perturbation and neuroimaging in non-human primates.NeuroImage · 2021Review
- Nonhuman Primate Models to Explore Mechanisms Underlying Early-Life Temperamental Anxiety.Biological psychiatry · 2021Review
- Sharing voxelwise neuroimaging results from rhesus monkeys and other species with Neurovault.NeuroImage · 2021Article
- Gut microbiome partially mediates and coordinates the effects of genetics on anxiety-like behavior in Collaborative Cross mice.Scientific reports · 2021Article
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Authors and funding
17 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundAn early-life anxious temperament (AT) is a risk factor for the development of anxiety, depression, and comorbid substance abuse. We validated a nonhuman primate model of early-life AT and identified the dorsal amygdala as a core component of AT's neural circuit. Here, we combine RNA sequencing, viral-vector gene manipulation, functional brain imaging, and behavioral phenotyping to uncover AT's molecular substrates.
methodsIn response to potential threat, AT and brain metabolism were assessed in 46 young rhesus monkeys. We identified AT-related transcripts using RNA-sequencing data from dorsal amygdala tissue (including central nucleus of the amygdala [Ce] and dorsal regions of the basal nucleus). Based on the results, we overexpressed the neurotrophin-3 gene, NTF3, in the dorsal amygdala using intraoperative magnetic resonance imaging-guided surgery (n = 5 per group).
resultsThis discovery-based approach identified AT-related alterations in the expression of well-established and novel genes, including an inverse association between NTRK3 expression and AT. NTRK3 is an interesting target because it is a relatively unexplored neurotrophic factor that modulates intracellular neuroplasticity pathways. Overexpression of the transcript for NTRK3's endogenous ligand, NTF3, in the dorsal amygdala resulted in reduced AT and altered function in AT's neural circuit.
conclusionsTogether, these data implicate neurotrophin-3/NTRK3 signaling in the dorsal amygdala in mediating primate anxiety. More generally, this approach provides an important step toward understanding the molecular underpinnings of early-life AT and will be useful in guiding the development of treatments to prevent the development of stress-related psychopathology.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.