ArticleTheoretical biology & medical modelling2019
Mathematical simulation of temperature distribution in tumor tissue and surrounding healthy tissue treated by laser combined with indocyanine green.
Article in Theoretical biology & medical modelling, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 36 citations in OpenAlex.
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- CO2 Fractional Laser Induced Skin Micro-Tunnel Thermal Damage Patterns: A Simulation Study.Journal of lasers in medical sciences · 2024Article
- 3D modeling of in vivo MRI-guided nano-photothermal therapy mediated by magneto-plasmonic nanohybrids.Biomedical engineering online · 2023Article
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- Experimental Evaluation of Radiation Response and Thermal Properties of NPs-Loaded Tissues-Mimicking Phantoms.Nanomaterials (Basel, Switzerland) · 2022Article
- Novel Photo- and Thermo-Responsive Nanocomposite Hydrogels Based on Functionalized rGO and Modified SIS/Chitosan Polymers for Localized Treatment of Malignant Cutaneous Melanoma.Frontiers in bioengineering and biotechnology · 2022Article
- Fractal Pennes and Cattaneo-Vernotte bioheat equations from product-like fractal geometry and their implications on cells in the presence of tumour growth.Journal of the Royal Society, Interface · 2021Article
- Multi-Wavelength Photo-Magnetic Imaging System for Photothermal Therapy Guidance.Lasers in surgery and medicine · 2021Article
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundPhotothermal therapy is a local treatment method for cancer and the heat energy generated from it could destroy the tumor cells. This study is aimed to investigate the temperature distribution in tumor tissue and surrounding health tissue of tumor bearing mice applying mathematical simulation model. Tumor bearing mice treated by laser combined with or without indocyanine green. Monte Carlo method and the Pennes bio-heat equation were used to calculate the light distribution and heat energy. COMSOL Multiphysic was adopted to construct three dimensional temperature distribution model.
resultsThis study revealed that the data calculated by simulation model is in good agreement with the surface temperature monitored by infrared thermometer. Effected by the optical parameters and boundary conditions of tissue, the highest temperature of tissue treated by laser combined with indocyanine green was about 65 °C which located in tumor tissue and the highest temperature of tissue treated by laser was about 43 °C which located under the tumor tissue. The temperature difference was about 20 °C. Temperature distribution in tissue was not uniform. The temperature difference in different parts of tumor tissue raised up to 15 °C. The temperature of tumor tissue treated by laser combined with indocyanine green was about 20 °C higher than that of the surrounding healthy tissue.
conclusionsReasonably good matching between the calculated temperature and the measured temperature was achieved, thus demonstrated great utility of our modeling method and approaches for deepening understand in the temperature distribution in tumor tissue and surrounding healthy tissue during the laser combined with photosensitizer. The simulation model could provide guidance and reference function for the effect of photothermal therapy.
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