Evidence map›Paper›PMID 31422757›Full record

ArticleJournal of feline medicine and surgery2020

Plasma homocysteine concentration in privately owned healthy adult cats: assessment of biological determinants and establishment of a reference interval.

Amandine Drut, Nicolas Soetart, Carole Bertin, Emmanuelle Le Corff, Caroline Berder, Chantal Thorin, Patrick Nguyen, Gilles Simard, M Yassine Mallem

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PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of feline medicine and surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 84% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Amandine DrutDepartment of Clinical Science, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.ORCID 0000-0002-8700-6004
Nicolas SoetartDepartment of Biology, Pathology and Food Science, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
Carole BertinDepartment of Biochemistry and Genetics, University Hospital, Angers, France.
Emmanuelle Le CorffDepartment of Clinical Science, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
Caroline BerderNutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
Chantal ThorinNutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
Patrick NguyenNutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
Gilles SimardDepartment of Biochemistry and Genetics, University Hospital, Angers, France.
M Yassine MallemNutrition, Physiopathology and Pharmacology Unit, Oniris - Nantes Atlantic National College of Veterinary Medicine, Food Science and Engineering, Nantes, France.
Oniris · FRUniversité d'Angers · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe assessment of homocysteine status in diseased cats has indicated high plasma concentrations in chronic kidney disease and yielded conflicting results with respect to cardiovascular disorders. Previous investigations in small populations of normal cats revealed greater-than-expected variability in plasma homocysteine concentration. The purpose of this study was to determine biological determinants and the reference interval (RI) of plasma homocysteine concentration in the feline species, under strict pre-analytical conditions.

methodsIn this prospective observational study, privately owned healthy adult cats underwent a complete physical examination, urinalysis and blood testing, in order to rule out any signs of disease. Plasma homocysteine concentration was measured using high-performance liquid chromatography-tandem mass spectrometry.

resultsOf 151 cats recruited, 30 cats were not included owing to abnormal physical examination or fractious behaviour, and 30 cats were excluded based on abnormalities on blood work or urinalysis. Plasma homocysteine concentrations >28 µmol/l were associated with a dietary protein content >9.3 g/100 kcal metabolisable energy. The RI for plasma homocysteine concentration was determined to be 6.2-52.3 µmol/l. CONCLUSIONS AND RELEVANCE: Normal values for plasma homocysteine concentration in cats have a wide RI, suggesting high inter-individual variability. Whether some healthy cats exhibit impaired homocysteine metabolism remains to be elucidated.

Indexed as

AnimalsCatsChromatography, High Pressure LiquidDietHomocysteineProspective StudiesReference ValuesHomocysteineCardiovascular diseasecobalaminfolatekidney disease

Identifiers

PMID31422757
PMCPMC10814430
OpenAlexW2969945265

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.