Evidence map›Paper›PMID 31422569›Full record

ArticleNeurotoxicity research2020

Ferulic Acid Modulates Dysfunctional Metabolic Pathways and Purinergic Activities, While Stalling Redox Imbalance and Cholinergic Activities in Oxidative Brain Injury.

Veronica F Salau, Ochuko L Erukainure, Collins U Ibeji, Tosin A Olasehinde, Neil A Koorbanally, Md Shahidul Islam

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
5.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 59 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Probiotic, Postbiotic, and Paraprobiotic Effects ofFoods (Basel, Switzerland) · 2024
    Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Anxiolytic-Pharmaceuticals (Basel, Switzerland) · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Frontiers in pharmacology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Veronica F SalauDepartment of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.
Ochuko L ErukainureDepartment of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.ORCID http://orcid.org/0000-0003-0489-338X
Collins U IbejiDepartment of Pure and Industrial Chemistry, Faculty of Physical Sciences, University of Nigeria, Nsukka, 410001, Nigeria.
Tosin A OlasehindeDepartment of Biochemistry and Microbiology, University of Fort Hare, Alice, Eastern Cape, 5700, South Africa.
Neil A KoorbanallySchool of Chemistry and Physics, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa.
Md Shahidul IslamDepartment of Biochemistry, University of KwaZulu-Natal, Westville Campus, Durban, 4000, South Africa. islamd@ukzn.ac.za.
University of KwaZulu-Natal · ZAFederal Institute of Industrial Research Oshodi · NGUniversity of Fort Hare · ZAUniversity of Nigeria · NGVeritas University · NG

Funding

National Research Foundation- the World Academy of Science (NRF-TWAS), Pretoria, South Africa 116106Research Office, University of KwaZulu-Natal, Durban, South Africa 218087036
6 · The paper itself

Abstract

The neuroprotective activities of phenolics have been demonstrated in several studies, with their antioxidant properties playing an influential role. In this study, the therapeutic effect of ferulic acid was investigated on oxidative stress, purinergic and cholinergic enzymatic activities, and dysregulated metabolic pathways in oxidative brain injury. Ferulic acid significantly elevated the reduced glutathione (GSH) level, superoxide dismutase and catalase activities, and concomitantly depleted malondialdehyde and nitric oxide level. It also inhibited the activities of acetylcholinesterase and butyrylcholinesterase, and increased the activities of ATPase. LC-MS analysis of the metabolites revealed restoration of most depleted metabolites, with concomitant generation of dihydroferulic acid 4-O-glucuronide, diadenosine heptaphosphate, cis-4-decenoic acid, ganglioside GT3 (d18:0/23:0), phosphatidylinositol-3,4,5-trisphosphate, and phosphoribosyl-ATP on treatment with ferulic acid. Pathway analysis of the identified metabolites revealed reactivation of oxidative-inactivated pathways, with concomitant activation of histidine and inositol phosphate metabolic pathways. There was no cytotoxicity on incubation of ferulic acid with HT22 cells. Molecular docking studies revealed a high affinity for acetylcholinesterase, with a binding energy of - 7.4 kcal/mol. In silico simulation analysis predicted permeability of ferulic acid across blood brain barrier (BBB) and an oral LD

Indexed as

AnimalsAnti-Inflammatory Agents, Non-SteroidalBrain InjuriesCell SurvivalCoumaric AcidsDose-Response Relationship, DrugFree Radical ScavengersLipid PeroxidationMaleMetabolic Networks and PathwaysOxidation-ReductionOxidative StressProtein Structure, SecondaryRatsRats, Sprague-DawleyReceptors, CholinergicAnti-Inflammatory Agents, Non-SteroidalCoumaric Acidsferulic acidFree Radical ScavengersReceptors, CholinergicReceptors, PurinergicAntioxidativeFerulic acidIron toxicityNeurodegenerative diseaseOxidative stress

Identifiers

PMID31422569
OpenAlexW2967347671

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.