Evidence map›Paper›PMID 31422549›Full record

ArticleCerebellum (London, England)2019

Tremor Distribution and the Variable Clinical Presentation of Essential Tremor.

Matteo Bologna, Isabella Berardelli, Giulia Paparella, Gina Ferrazzano, Luca Angelini, Patrizia Giustini, Danilo Alunni-Fegatelli, Alfredo Berardelli

Abstract read
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Neuropsychiatric, stress-related symptoms and essential tremor clinical variability.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Article
  5. Article
  6. Pathophysiological Role of Primary Motor Cortex in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Clinical and kinematic characterization of parkinsonian soft signs in essential tremor.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Article
  13. Article
  14. Article
  15. Article
  16. A Novel KCNQ2 Variant in a Patient with a Combined Tremor Syndrome.Tremor and other hyperkinetic movements (New York, N.Y.) · 2024
    Article
  17. The role of laboratory investigations in the classification of tremors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matteo BolognaDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Isabella BerardelliDepartment of Neurosciences, Mental Health and Sensory Organs, Suicide Prevention Center, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
Giulia PaparellaIRCCS Neuromed, Pozzilli, IS, Italy.
Gina FerrazzanoIRCCS Neuromed, Pozzilli, IS, Italy.
Luca AngeliniDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Patrizia GiustiniDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università, 30, 00185, Rome, Italy.
Danilo Alunni-FegatelliDepartment of Public Health and Infectious Disease, Sapienza University of Rome, Rome, Italy.
Alfredo BerardelliDepartment of Human Neurosciences, Sapienza University of Rome, Viale dell'Università, 30, 00185, Rome, Italy. alfredo.berardelli@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In addition to having postural and kinetic tremor of the upper limbs, some patients with essential tremor (ET) may have head tremor as well as cognitive and psychiatric disorders. We aimed to investigate whether the variable clinical presentation in ET patients, including motor and non-motor symptoms, differs in patients with and without head tremor. We consecutively enrolled 70 patients with a diagnosis of ET. Tremor severity was assessed by means of clinical rating scales. Patients also underwent kinematic recordings of postural and kinetic tremor of the upper limbs based on an optoelectronic system. Several neuropsychological tests were also administered. Finally, we adopted the structured interviews for DSM-IV, SCID-I, and SCID-II to investigate psychiatric and personality disorders. ET patients with upper limb tremor plus head tremor exhibited more severe kinetic tremor of the upper limbs and a higher occurrence of axis I psychiatric disorders than ET patients with upper limb tremor only. Cognitive and other motor and psychiatric features did not differ significantly with respect to tremor distribution. The study findings support the hypothesis that body tremor distribution, i.e., the presence of head tremor, influences the variable clinical presentation of ET. The study results support the notion that cases with head tremor may represent a distinct ET subtype, characterized by a prominent cerebellar involvement, and that psychiatric disorders should be considered as a specific manifestation of ET.

Indexed as

AdultAgedAged, 80 and overEssential TremorFemaleHeadHumansMaleMental DisordersMiddle AgedProspective StudiesUpper ExtremityYoung AdultCognitive disordersEssential tremorHead tremorNeurophysiologyPsychiatric symptoms

Identifiers

PMID31422549

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.