ArticleMetabolomics : Official journal of the Metabolomic Society2019
Tissue, urine and blood metabolite signatures of chronic kidney disease in the 5/6 nephrectomy rat model.
Article in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
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- Multiplatform Metabolomic Profiling of the Unilateral Ureteral Obstruction Murine Model of CKD.International journal of molecular sciences · 2025Article
- Whole Blood Metabolomic Profiling of Mice with Tacrolimus-Induced Chronic Nephrotoxicity: NADAntioxidants (Basel, Switzerland) · 2025Article
- CKD Urine Metabolomics: Modern Concepts and Approaches.Pathophysiology : the official journal of the International Society for Pathophysiology · 2023Review
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- Shenkang Injection for Treating Renal Fibrosis-Metabonomics and Regulation of E3 Ubiquitin Ligase Smurfs on TGF-β/Smads Signal Transduction.Frontiers in pharmacology · 2022Article
- Identifying metabolic alterations in newly diagnosed small cell lung cancer patients.Metabolism open · 2021Article
- Characterising Alzheimer's disease through integrative NMR- and LC-MS-based metabolomics.Metabolism open · 2021Article
- Associations of Plasma Glucagon Levels with Estimated Glomerular Filtration Rate, Albuminuria and Diabetic Kidney Disease in Patients with Type 2 Diabetes Mellitus.Diabetes & metabolism journal · 2021Article
- Diet, obesity, and the gut microbiome as determinants modulating metabolic outcomes in a non-human primate model.Microbiome · 2021Article
- Tissue, urine and serum NMR metabolomics dataset from a 5/6 nephrectomy rat model of chronic kidney disease.Data in brief · 2020Article
- Metabolomics profiling in hypertension and blood pressure regulation: a review.Clinical hypertension · 2020Review
- A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- DAXX mediates high phosphate-induced endothelial cell apoptosis in vitro through activating ERK signaling.PeerJ · 2020Article
- Citrate NMR peak irreproducibility in blood samples after reacquisition of spectra.Metabolomics : Official journal of the Metabolomic Society · 2019Article
- FGF23-Mediated Activation of Local RAAS Promotes Cardiac Hypertrophy and Fibrosis.International journal of molecular sciences · 2019Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionProgressive chronic kidney disease (CKD) is an important cause of morbidity and mortality. It has a long asymptomatic phase, where routine blood tests cannot identify early functional losses, and therefore identifying common mechanisms across the many etiologies is an important goal.
objectivesOur aim was to characterize serum, urine and tissue (kidney, lung, heart, spleen and liver) metabolomics changes in a rat model of CKD.
methodsA total of 17 male Wistar rats underwent 5/6 nephrectomy, whilst 13 rats underwent sham operation. Urine samples were collected weekly, for 6 weeks; blood was collected at weeks 0, 3 and 6; and tissue samples were collected at week 6. Samples were analyzed on a nuclear magnetic resonance spectroscopy platform with multivariate and univariate data analysis.
resultsChanges in several metabolites were statistically significant. Allantoin was affected in all compartments. Renal asparagine, creatine, hippurate and trimethylamine were significantly different; in other tissues creatine, dimethylamine, dimethylglycine, trigonelline and trimethylamine were significant. Benzoate, citrate, dimethylglycine, fumarate, guanidinoacetate, malate, myo-inositol and oxoglutarate were altered in urine or serum.
conclusionAlthough the metabolic picture is complex, we suggest oxidative stress, the gut-kidney axis, acid-base balance, and energy metabolism as promising areas for future investigation.
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