ArticleEuropean archives of psychiatry and clinical neuroscience2021
Impaired working memory performance in opioid-dependent patients is related to reduced insula gray matter volume: a voxel-based morphometric study.
Article in European archives of psychiatry and clinical neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Effect of Overdose-Induced Hypoxia on Neurocognitive Performance in Individuals With Opioid Dependence: A Prospective Multicenter Study.Alpha psychiatry · 2026Article
- Prescription Pain Medication Misuse with and Without Heroin Use Among Adolescents: relationships with Routine Healthcare, Family Support, Academic Performance, Violence, and Other Risky Behaviors.Substance use & misuse · 2025Article
- Causal functional maps of brain rhythms in working memory.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Neurocognitive performance of patients undergoing intravenous versus oral opioid agonist treatment: a prospective multicenter study on three-month treatment effects.Frontiers in psychiatry · 2024Article
- Cognitive Alterations in Addictive Disorders: A Translational Approach.Biomedicines · 2023Review
- Common and distinct fronto-striatal volumetric changes in heroin and cocaine use disorders.Brain : a journal of neurology · 2023Article
- Effects of current smoking severity on brain gray matter volume in opioid use disorder - a voxel-based morphometry study.The American journal of drug and alcohol abuse · 2023Article
- Extra cup of tea intake associated with increased risk of Alzheimer's disease: Genetic insights from Mendelian randomization.Frontiers in nutrition · 2023Article
- An fMRI analysis of verbal and non-verbal working memory in people with a past history of opioid dependence.Frontiers in neuroscience · 2023Article
- Characterization of basal ganglia volume changes in the context of HIV and polysubstance use.Scientific reports · 2022Article
- Mindful Positive Emotion Regulation as a Treatment for Addiction: From Hedonic Pleasure to Self-Transcendent Meaning.Current opinion in behavioral sciences · 2021Article
- The molecular neurobiology and neuropathology of opioid use disorder.Current research in neurobiology · 2021Article
- Substance-Specific and Shared Gray Matter Signatures in Alcohol, Opioid, and Polysubstance Use Disorder.Frontiers in psychiatry · 2021Article
- Brain Cortical Complexity Alteration in Amyotrophic Lateral Sclerosis: A Preliminary Fractal Dimensionality Study.BioMed research international · 2020Article
- Coenzyme Q10 Suppression of Cue-related Reinstatement Through Cognition Improvement and Hippocampal Increase in BDNF Expression in Morphine-dependent Male Rats.Basic and clinical neuroscienceArticle
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Opioid-dependent patients frequently show deficits in multiple cognitive domains that might impact on their everyday life performance and interfere with therapeutic efforts. To date, the neurobiological underpinnings of those deficits remain to be determined. We investigated working memory performance and gray matter volume (GMV) differences in 17 patients on opioid maintenance treatment (OMT) and 17 healthy individuals using magnetic resonance imaging and voxel-based morphometry. In addition, we explored associations between substance intake, gray matter volume, and working memory task performance. Patients on OMT committed more errors during the working memory task than healthy individuals and showed smaller insula and putamen GMV. The duration of heroin use prior to OMT was associated with working memory performance and insula GMV in patients. Neither the substitution agent (methadone and buprenorphine) nor concurrent abuse of illegal substances during the 3 months prior to the experiment was significantly associated with GMV. Results indicate that impaired working memory performance and structural deficits in the insula of opioid-dependent patients are related to the duration of heroin use. This suggests that early inclusion into OMT or abstinence-oriented therapies that shorten the period of heroin abuse may limit the impairments to GMV and cognitive performance of opioid-dependent individuals.
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