Evidence map›Paper›PMID 31422380›Full record

ArticleAging2019

Rejuvenation of brain, liver and muscle by simultaneous pharmacological modulation of two signaling determinants, that change in opposite directions with age.

Melod Mehdipour, Jessy Etienne, Chia-Chien Chen, Ranveer Gathwala, Maryam Rehman, Cameron Kato, Chao Liu, Yutong Liu, Yi Zuo, Michael J Conboy and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 36 citations in OpenAlex.

  1. Oxytocin as regulator of stress and inflammation in aging.Neuroscience and biobehavioral reviews · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Transplantation to study satellite cell heterogeneity in skeletal muscle.Frontiers in cell and developmental biology · 2022
    Review
  15. Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Melod MehdipourDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Jessy EtienneDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Chia-Chien ChenDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Ranveer GathwalaDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Maryam RehmanDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Cameron KatoDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Chao LiuDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Yutong LiuDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Yi ZuoDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, CA 95064, USA.
Michael J ConboyDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
Irina M ConboyDepartment of Bioengineering and QB3 Institute, University of California, Berkeley, Berkeley, CA 94720, USA.
QB3 · USUniversity of California, Berkeley · USUniversity of California, Santa Cruz · US

Funding

Dynamics and molecular mechanism of synaptic connectivity change during learningR01MH104227 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2014 to 2018
$2.1M
Contribution of astrocytes to the Fragile X SyndromeR01MH109475 · NIMH · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI ZUO, YI · 2016 to 2020
$2.0M
New Generation Blood Exchange Devices for Enhancing Tissue Regeneration and HealthR01HL139605 · NHLBI · UNIVERSITY OF CALIFORNIA BERKELEY · PI ARAN, KIANA, CONBOY, IRINA M · 2018 to 2021
$1.6M
Defined pharmacology for multi-tissue rejuvenation acting through youthful normalization of p16R56AG058819 · NIA · UNIVERSITY OF CALIFORNIA BERKELEY · PI CONBOY, IRINA M · 2018 to 2018
$381k
NHLBI NIH HHS R01 HL139605NIA NIH HHS R56 AG058819NIMH NIH HHS R01 MH104227NIMH NIH HHS R01 MH109475
6 · The paper itself

Abstract

We hypothesize that altered intensities of a few morphogenic pathways account for most/all the phenotypes of aging. Investigating this has revealed a novel approach to rejuvenate multiple mammalian tissues by defined pharmacology. Specifically, we pursued the simultaneous youthful in vivo calibration of two determinants: TGF-beta which activates ALK5/pSmad 2,3 and goes up with age, and oxytocin (OT) which activates MAPK and diminishes with age. The dose of Alk5 inhibitor (Alk5i) was reduced by 10-fold and the duration of treatment was shortened (to minimize overt skewing of cell-signaling pathways), yet the positive outcomes were broadened, as compared with our previous studies. Alk5i plus OT quickly and robustly enhanced neurogenesis, reduced neuro-inflammation, improved cognitive performance, and rejuvenated livers and muscle in old mice. Interestingly, the combination also diminished the numbers of cells that express the CDK inhibitor and marker of senescence p16 in vivo. Summarily, simultaneously re-normalizing two pathways that change with age in opposite ways (up vs. down) synergistically reverses multiple symptoms of aging.

Indexed as

RejuvenationAgingAnimalsBrainCognitionInflammationLiverMaleMiceMice, Inbred C57BLMitogen-Activated Protein KinasesMuscle, SkeletalNeurogenesisOxytocinPsychomotor PerformanceReceptor, Transforming Growth Factor-beta Type IMitogen-Activated Protein KinasesOxytocinReceptor, Transforming Growth Factor-beta Type ISmad ProteinsTGFBR1 protein, humanTransforming Growth Factor betacognitionliver healthmuscle repairneurogenesisneuro-inflammationoxytocinTGF-beta

Identifiers

PMID31422380
PMCPMC6710051
OpenAlexW2968889651

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.