Evidence map›Paper›PMID 31421507›Full record

Trial reportNeuroImage. Clinical2019

White matter integrity is associated with gait impairment and falls in mild cognitive impairment. Results from the gait and brain study.

Jonatan A Snir, Robert Bartha, Manuel Montero-Odasso

Registry-linked trialOpen access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage. Clinical, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03020381 (Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03020381 recruitingnot on this map

Gait as Predictor of Cognitive Decline, Dementia, and Risk of Falls in MCI. A Cohort Study

TypeobservationalSponsorManuel Montero OdassoRan2007 to 2033Enrolled600ConditionsGait Apraxia, Mild Cognitive Impairment, Subjective Cognitive Impairment, Cerebral Atrophy
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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  9. Lower Myelin Content Is Associated With Lower Gait Speed in Cognitively Unimpaired Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jonatan A SnirGait and Brain Lab, Parkwood Institutel, Lawson Health Research Institute, London, Ontario, Canada; The Centre for Functional and Metabolic Mapping, Robarts Research Institute, Departments of Medical Biophysics, Medical Imaging, and Psychiatry, University of Western Ontario, London, Ontario, Canada.
Robert BarthaThe Centre for Functional and Metabolic Mapping, Robarts Research Institute, Departments of Medical Biophysics, Medical Imaging, and Psychiatry, University of Western Ontario, London, Ontario, Canada.
Manuel Montero-OdassoGait and Brain Lab, Parkwood Institutel, Lawson Health Research Institute, London, Ontario, Canada; Schulich School of Medicine and Dentistry, Department of Medicine and Division of Geriatric Medicine, London, Ontario, Canada; Department of Epidemiology and Biostatistics, University of Western Ontario, London, Ontario, Canada. Electronic address: mmontero@uwo.ca.
Western University · CA

Funding

CIHR MOP 211220CIHR PJT 153100
6 · The paper itself

Abstract

backgroundMild Cognitive Impairment (MCI) is an intermediate state between normal cognition and dementia that is associated with twice the risk of falls. It is unknown whether white matter integrity (WMI) is associated with increased risk of falls in MCI. The purpose of this study was to evaluate if early changes in WMI were associated with gait impairment and falls.

methodsForty-three participants with MCI from the Gait and Brain Study underwent standardized assessment of cognition, gait performance under single and dual-task conditions (walking while talking), and WMI using 3 Tesla diffusion tensor imaging (DTI). Macro-structural imaging characteristics (white and grey matter morphology) as well as microstructural WMI parameters were examined for associations with falls and gait performance. Significantly associated WM tracts were then used to test the interplay between WMI and history of falls, after adjusting for other important covariates.

resultsMultiple WM tracts (corpus callosum, forceps minor, and the left inferior fronto-occipital fasciculus) were significantly associated with history of falls and lower dual-task gait performance. A multivariable regression model showed that fall history was associated with the radial diffusivity in the forceps minor, even after adjusting for education, sex, BMI, MMSE scores, comorbidities, gait velocity and WMH volume as covariates.

conclusionsMultiple WM tracts that are known to be involved in executive and visuospatial functions were preferentially affected in MCI individuals with history of falls. Our preliminary findings support the notion that WMI in key brain regions may increase risk of falls in older adults with MCI.

Indexed as

Accidental FallsAgedAged, 80 and overCognitive DysfunctionDiffusion Tensor ImagingExecutive FunctionFemaleGait Disorders, NeurologicHumansMalePsychomotor PerformanceSpace PerceptionVisual PerceptionWalkingWhite MatterDiffusion tensor imagingExecutive functionFallsGaitMCIMicrostructureWhite matter

Identifiers

PMID31421507
PMCPMC6706343
OpenAlexW2965430693

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.