Evidence map›Paper›PMID 31421411›Full record

ArticleRedox biology2019

OxyR senses sulfane sulfur and activates the genes for its removal in Escherichia coli.

Ningke Hou, Zhenzhen Yan, Kaili Fan, Huanjie Li, Rui Zhao, Yongzhen Xia, Luying Xun, Huaiwei Liu

Open access · goldAbstract read
In one paragraph

Article in Redox biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 63 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Antioxidants (Basel, Switzerland) · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. OxyR contributes to the oxidative stress capacity and virulence of hypervirulentFrontiers in cellular and infection microbiology · 2025
    Article
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Metabolites · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ningke HouState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Zhenzhen YanState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Kaili FanState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Huanjie LiState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Rui ZhaoState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Yongzhen XiaState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China.
Luying XunState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China; School of Molecular Biosciences, Washington State University, Pullman, WA, 99164-7520, USA. Electronic address: luying_xun@vetmed.edu.edu.
Huaiwei LiuState Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, People's Republic of China. Electronic address: liuhuaiwei@sdu.edu.cn.
Shandong University · CNState Key Laboratory of Microbial Technology

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sulfane sulfur species including hydrogen polysulfide and organic persulfide are newly recognized normal cellular components, and they participate in signaling and protect cells from oxidative stress. Their production has been extensively studied, but their removal is less characterized. Herein, we showed that sulfane sulfur at high levels was toxic to Escherichia coli under both anaerobic and aerobic conditions. OxyR, a well-known regulator against H

Indexed as

Chromatography, LiquidEscherichia coliEscherichia coli ProteinsGene Expression ProfilingGene Expression Regulation, BacterialHydrogen PeroxideHydrogen SulfideMutationOxidation-ReductionRepressor ProteinsSulfurTandem Mass SpectrometryThioredoxinsTranscriptional ActivationEscherichia coli ProteinsHydrogen PeroxideHydrogen SulfideoxyR protein, E coliRepressor ProteinsSulfurThioredoxinsEscherichia coliGlutaredoxinOxyRSulfane sulfurThioredoxin

Identifiers

PMID31421411
PMCPMC6831875
OpenAlexW2967218891

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.