Evidence map›Paper›PMID 31421233›Full record

ArticleJournal of the American Academy of Child and Adolescent Psychiatry2020

Trajectories of Growth Associated With Long-Term Stimulant Medication in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder.

Laurence L Greenhill, James M Swanson, Lily Hechtman, James Waxmonsky, L Eugene Arnold, Brooke S G Molina, Stephen P Hinshaw, Peter S Jensen, Howard B Abikoff, Timothy Wigal and 5 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Academy of Child and Adolescent Psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00000388 (Multimodal Treatment Study of Children With ADHD), which is not on this map. Cited by 32 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 5 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00000388 phase4completednot on this map

Multimodal Treatment Study of Children With ADHD

TypeinterventionalSponsorNYU Langone HealthRan1998 to 1999ConditionsAttention Deficit Disorder With Hyperactivity, Substance-related Disorders, Dyssocial BehaviorArmsPsychosocial treatment, Anti-ADHD medication, Assessment-and-Referral
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 5 syntheses or guidelines pooled it, 69 citations in OpenAlex.

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  19. Methylphenidate Promotes Premature Growth Plate Closure: In Vitro Evidence.International journal of molecular sciences · 2023
    Article
  20. Ghrelin regulates hyperactivity-like behaviorsFrontiers in endocrinology · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 11 institutions in 4 countries.

Laurence L GreenhillDivision of Child Psychiatry, New York State Psychiatric Institute, and Columbia University, New York, NY. Electronic address: larrylgreenhill@gmail.com.
James M SwansonSchool of Medicine, University of California, Irvine.
Lily HechtmanDivision of Child Psychiatry, McGill University, Montreal Children's Hospital, Montreal, Quebec, Canada.
James WaxmonskyPennsylvania State University Division of Child and Adolescent Psychiatry, Centre County.
L Eugene ArnoldOhio State University, Nisonger Center, Columbus.
Brooke S G MolinaUniversity of Pittsburgh School of Medicine, Pennsylvania.
Stephen P HinshawUniversity of California, Berkeley, and the University of California, San Francisco.
Peter S JensenUniversity of Arkansas for Medical Sciences, Little Rock, and The REACH Institute, New York, NY.
Howard B AbikoffDivision of Child Psychiatry, New York State Psychiatric Institute, and Columbia University, New York, NY.
Timothy WigalClinical Services for Avida Inc., Newport Beach, California.
Annamarie StehliUniversity of California, Irvine.
Andrea HowardCarleton University, Ottawa, Ontario, Canada.
Michael HermanussenUniversity of Kiel, Kiel, Germany.
Tomasz HanćAdam Mickiewicz University, Poznan, Poland.
MTA Cooperative Group
New York Psychoanalytic Society and Institute · USUniversity of California, Irvine · USAdam Mickiewicz University in Poznań · PLCarleton University · CAChristian-Albrechts-Universität zu Kiel · DEMontreal Children's Hospital · CAPennsylvania State University · USThe Ohio State University Wexner Medical Center · USUniversity of Arkansas for Medical Sciences · USUniversity of California, San Francisco · USUniversity of Pittsburgh · US

Funding

A Novel Approach to Stimulant-Induced Weight Suppression and its Impact on GrowthR01MH083692 · NIMH · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI PELHAM, WILLIAM E, WAXMONSKY, JAMES GAIER · 2009 to 2014
$3.1M
Emotion Dysregulation, ADHD, and SmokingK23DA032577 · NIDA · DUKE UNIVERSITY · PI MITCHELL, JOHN T · 2012 to 2015
$566k
PHARMACOLOGIC AND PSYCHOSOCIAL INTERVENTIONS FOR ADHDU01MH050461 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI HINSHAW, STEPHEN P · 1992 to 2000
$17k
MULTISITE MULTIMODAL TREATMENT STUDY OF ADHD/ADDU01MH050453 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ABIKOFF, HOWARD B · 1992 to 2000
$17k
MULTISITE MULTIMODALITY TREATMENT STUDY OF ADHD/ADDU01MH050440 · NIMH · UNIVERSITY OF CALIFORNIA IRVINE · PI SWANSON, JAMES M · 1992 to 2000
$17k
PHARMACOLOGICAL AND PSYCHOSOCIAL TREATMENT FOR ADHDU01MH050467 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI PELHAM, WILLIAM E · 1992 to 2000
$17k
FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012011N01MH012011 · NIMH · UNIVERSITY OF CALIFORNIA, IRVI · PI SWANSON, JAMES · 2002 to 2006
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012012N01MH012012 · NIMH · DUKE UNIVERSITY MEDICAL CENTER · 2002 to 2004
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FOLLOW UP OF THE MULTIMODAL TREATMETN STUDY OF CHILDREN WITH ATTENTION-278012010N01MH012010 · NIMH · UNIVERSITY OF PITTSBURGH · PI SG MOLINA, BROOKE · 2002 to 2006
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012009N01MH012009 · NIMH · UNIVERSITY OF CALIFORNIA, BERK · PI HINSHAW, STEPHEN · 2002 to 2006
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FOLLOW-UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012008N01MH012008 · NIMH · MCGILL UNIVERSITY · PI HECHTMAN, LILY T. · 2002 to 2006
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FOLLOW UP OF THE MULTIMODAL TREATMENT STUDY OF CHILDREN WITH ATTENTION-278012007N01MH012007 · NIMH · RES. FOUND. FOR MENTAL HEALTH, · PI GREENHILL, LARRY LEE · 2002 to 2006
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6 · The paper itself

Abstract

objectiveTo estimate long-term stimulant treatment associations on standardized height, weight, and body mass index trajectories from childhood to adulthood in the Multimodal Treatment Study of Attention-Deficit/Hyperactivity Disorder (MTA).

methodOf 579 children with DSM-IV ADHD-combined type at baseline (aged 7.0-9.9 years) and 289 classmates (local normative comparison group [LNCG]), 568 and 258 respectively, were assessed 8 times over 16 years (final mean age = 24.7). Parent interview data established subgroups with self-selected Consistent (n = 53, 9%), Inconsistent (n = 374, 66%), and Negligible (n = 141, 25%) stimulant medication use, as well as patients starting stimulants prior to MTA entry (n = 211, 39%). Height and weight growth trajectories were calculated for each subgroup.

resultsHeight z scores trajectories differed among subgroups (F = 2.22, p < .0001) and by stimulant use prior to study entry (F = 2.22, p < .001). The subgroup-by-assessment interaction was significant (F = 2.81, p < .0001). Paired comparisons revealed significant subgroup differences at endpoint: Consistent was shorter than Negligible (-0.66 z units /-4.06 cm /1.6 inches, t = -3.17, p < 0.0016), Consistent shorter than Inconsistent (-0.45 z units /-2.74 cm /-1.08 inches, t = -2.39, p < .0172), and the Consistent shorter than LNCG (-0.54 z units/+3.34 cm/ 1.31 inches, t = -3.30, p < 0.001). Weight z scores initially diverged among subgroups, converged in adolescence, and then diverged again in adulthood when the Consistent outweighed the LNCG (+ 3.561 z units /+7.47 kg /+16.46 lb, p < .0001).

conclusionCompared with those negligibly medicated and the LNCG, 16 years of consistent stimulant treatment of children with ADHD in the MTA was associated with changes in height trajectory, a reduction in adult height, and an increase in weight and body mass index. CLINICAL TRIAL REGISTRATION INFORMATION: Multimodal Treatment Study of Children With Attention Deficit and Hyperactivity Disorder (MTA); https://clinicaltrials.gov/; NCT00000388.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsAdolescentAdultBody Mass IndexBody WeightChildCombined Modality TherapyHumansYoung AdultCentral Nervous System StimulantsADHDadult heightgrowth trajectorylongitudinal studystimulant medication

Identifiers

PMID31421233
PMCPMC7021562
OpenAlexW2968111141

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.