Evidence map›Paper›PMID 31421228›Full record

ArticleReproductive toxicology (Elmsford, N.Y.)2020

In utero DDT exposure and breast density in early menopause by maternal history of breast cancer.

Jasmine A McDonald, Piera M Cirillo, Parisa Tehranifar, Nickilou Y Krigbaum, Natalie J Engmann, Barbara A Cohn, Mary Beth Terry

Open access · greenAbstract read
In one paragraph

Article in Reproductive toxicology (Elmsford, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Grandmaternal Perinatal Serum DDT in Relation to Granddaughter Early Menarche and Adult Obesity: Three Generations in the Child Health and Development Studies Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021
    Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. In utero DDT exposure and breast density before age 50.Reproductive toxicology (Elmsford, N.Y.) · 2020
    Article
  11. CHDS: A national treasure that keeps on giving.Reproductive toxicology (Elmsford, N.Y.) · 2020
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jasmine A McDonaldDepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, 722 West 168th Street, New York, New York, United States; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York, 10032, United States. Electronic address: jam2319@cumc.columbia.edu.
Piera M CirilloChild Health and Development Studies, Public Health Institute, Berkeley, California, United States. Electronic address: pcirillo@chdstudies.org.
Parisa TehranifarDepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, 722 West 168th Street, New York, New York, United States; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York, 10032, United States. Electronic address: pt140@cumc.columbia.edu.
Nickilou Y KrigbaumChild Health and Development Studies, Public Health Institute, Berkeley, California, United States. Electronic address: nkrigbaum@chdstudies.org.
Natalie J EngmannDepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, 722 West 168th Street, New York, New York, United States. Electronic address: nengmann@gmail.com.
Barbara A CohnChild Health and Development Studies, Public Health Institute, Berkeley, California, United States. Electronic address: bcohn@chdstudies.org.
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University Irving Medical Center, 722 West 168th Street, New York, New York, United States; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, New York, 10032, United States. Electronic address: mt146@cumc.columbia.edu.
Columbia University Irving Medical Center · USBerkeley Public Health Division · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MATTHEW S PERZANOWSKI · 1998 to 2026
$44.7M
Meeting AccountU01ES019457 · NIEHS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HIATT, ROBERT A · 2010 to 2014
$3.2M
Childhood Infection and Pubertal TimingK01CA186943 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MCDONALD, JASMINE ALISE · 2015 to 2020
$751k
NCI NIH HHS K01 CA186943NIEHS NIH HHS P30 ES009089NIEHS NIH HHS U01 ES019457
6 · The paper itself

Abstract

We examined the relationship between intrauterine dichlorodiphenyltrichloroethane (DDT) exposure (o,p'-DDT, p,p'-DDT, and p,p'-DDE) and mammographic breast density (MBD) in midlife, one of the strongest risk factors for breast cancer. We focused our analyses on o,p'-DDT exposure given our previous report of a positive association between intrauterine o,p'-DDT exposure and daughter's breast cancer (BC) risk. Here we estimated associations of intrauterine serum DDTs with MBD in 224 daughters of women in the Child Health and Development Studies pregnancy cohort whose mothers did not develop BC (MBCa-) and 156 daughters whose mothers did develop BC (MBCa+). In MBCa+ daughters, highest relative to lowest quartile of o,p'-DDT exposure was associated with a 17-unit higher dense area (95% CI = 2.6-31.2; P

Indexed as

Breast DensityDDTEnvironmental PollutantsPesticidesBreastBreast NeoplasmsCaliforniaCohort StudiesFemaleHumansMaternal ExposureMaternal-Fetal ExchangeMedical History TakingMiddle AgedPregnancyPrenatal Exposure Delayed EffectsDDTEnvironmental PollutantsPesticidesChild health and development studiesDDT organochlorinesDense areaIn utero exposureMammographic breast densityNondense areaPercent density

Identifiers

PMID31421228
PMCPMC7018589
OpenAlexW2967388225

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.