ArticleArthritis care & research2020
Longitudinal Study of Fatigue, Stress, and Depression: Role of Reduction in Stress Toward Improvement in Fatigue.
Article in Arthritis care & research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Sarcopenia, Depression, Fatigue, and Fear of Falling in Middle-Aged and Older Adults With Visual Impairment: Empirical Research Quantitative.Nursing open · 2026Article
- Stress exposure prior to diagnosis and clinical characteristics in systemic lupus erythematosus: a cross-sectional study.Rheumatology international · 2026Article
- The Relationship Between Pain and Depression in Fibromyalgia: Structural Equation Modeling and Network Analysis.International journal of environmental research and public health · 2026Article
- Job Role and Organizational Commitment Among Chinese Rural Teachers: The Effects of Emotional Exhaustion and Teacher Resilience.Safety and health at work · 2026Article
- Associations among mental health promotion, sleep concerns, fatigue, and stress in clinical nurses: network and latent profile analysis.Frontiers in public health · 2026Article
- Psychological well-being of SLE patients: A comprehensive examination of stress, depression, anxiety and quality of life.PloS one · 2026Article
- Identifying core symptom clusters based on symptom distress levels in patients with maintenance hemodialysis: a cross-sectional network analysis.Renal failure · 2025Article
- Differential associations of passively sensed behaviors with in-vivo depression symptoms.Journal of psychopathology and clinical science · 2025Article
- Chain mediating effect of fatigue, anxiety symptoms on the relationship between perceived stress and insomnia in Chinese researchers.BMC public health · 2025Article
- Association Between Perceived Stress and Fatigue Severity in Patients With Chronic Illnesses.Cureus · 2025Article
- Fatigue and associated factors among patients with systemic lupus erythematosus in China: a cross-sectional study.Frontiers in medicine · 2025Article
- Positive psychosocial factors may protect against perceived stress in people with systemic lupus erythematosus with and without trauma history.Lupus science & medicine · 2024Article
- Article
- Predicting non-improvement of symptoms in daily mental healthcare practice using routinely collected patient-level data: a machine learning approach.Frontiers in psychiatry · 2023Article
- Symptom-Based Cluster Analysis Categorizes Sjögren's Disease Subtypes: An International Cohort Study Highlighting Disease Severity and Treatment Discordance.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Fatigue have impact on the sexual problems in Chinese females with systemic lupus erythematosus.BMC women's health · 2022Article
- Predictors of stress in patients with Lupus.Frontiers in medicine · 2022Article
- Chronic Restraint Stress-Induced Muscle Atrophy Leads to Fatigue in Mice by Inhibiting the AMPK Signaling Pathway.Biomedicines · 2021Article
- Fatigue in Systemic Lupus Erythematosus: An Update on Its Impact, Determinants and Therapeutic Management.Journal of clinical medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
objectiveFatigue is common among individuals with systemic lupus erythematosus (SLE), but the causes are not well understood. Our objective was to examine perceived stress and depressive symptoms as predictors of fatigue in SLE.
methodsData from 2 years of the Lupus Outcomes Study (n = 650 patients), obtained through annual structured interviews, were used. Fatigue was measured with the Short Form 36 (SF-36) vitality scale along with a variety of self-report measures of disease, depression, and stress. Multivariate linear regression models examined predictors of changes in fatigue. Model 1 tested the association of time 1 (T1) depression with time 2 (T2) fatigue; model 2 added T1 perceived stress to model 1, and final models added T1-to-T2 decrease in stress. All analyses controlled for T1 fatigue, age, sex, self-report of fibromyalgia, pain, and SLE duration, activity, and damage.
resultsMean ± SD age was 51 ± 12 years, 92% of participants were women, and 68% were white. The mean ± SD SF-36 fatigue score was 55 ± 24. T1 depression significantly predicted T2 fatigue. When T1 stress was added, stress (β = 1.7 [95% confidence interval (95% CI) 1.1, 2.2]; P < 0.0001) significantly predicted T2 fatigue, but depression was no longer significant. The addition of T1-to-T2 decrease in stress was associated with a clinically meaningful decline in fatigue (β = -11.8 [95% CI -15.6, -8.9]; P < 0.0001).
conclusionWhile depressive symptoms initially predicted subsequent fatigue, the effects were mediated by stress. A decrease in stress, in addition, was associated with a clinically meaningful decrease in fatigue. These results suggest that perceived stress plays an important role in SLE fatigue and may be an important focus of interventions for fatigue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.