ArticleLiver international : official journal of the International Association for the Study of the Liver2019
The value of different CT-based methods for diagnosing low muscle mass and predicting mortality in patients with cirrhosis.
Article in Liver international : official journal of the International Association for the Study of the Liver, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 1 of them a synthesis that pooled it.
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41 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
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- [The value of the nutritional assessment index or score in prognostic evaluation for patients with liver cancer].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Risk factors and prediction model for sarcopenia in patients with cirrhosis undergoing transjugular intrahepatic portosystemic shunt.Internal and emergency medicine · 2026Article
- Comparing efficacy of different scoring models to predict hepatic encephalopathy after TIPS in cirrhotic patients.Annals of medicine · 2025Article
- Paraspinous muscle sarcopenic indices for predicting mortality in patients undergoing hemodialysis.Renal failure · 2025Article
- A GLIM-defined malnutrition-based model for predicting prognosis of cirrhotic patients with portal hypertension following TIPS procedure.BMC gastroenterology · 2025Article
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- Clinical Features and Prevalence of Osteosarcopenia in Chronic Pancreatitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Observational
- Prevalence of locomotive syndrome and associated factors in patients receiving hemodialysis.Medicine · 2025Observational
- Skeletal Muscle Measurements Based on Abdominal Computerized Tomography (CT) Predict Risk of Osteoporosis in Incident Hemodialysis Patients.Journal of clinical medicine · 2024Article
- Sarcopenia evaluated by EASL/AASLD computed tomography-based criteria predicts mortality in patients with cirrhosis: A systematic review and meta-analysis.JHEP reports : innovation in hepatology · 2024Article
- Clinical usefulness of psoas muscle thickness for the prognosis of acute type A aortic dissection patients undergoing total arch replacement.Journal of thoracic disease · 2024Article
- Imaging-based diagnosis of sarcopenia for transplant-free survival in primary sclerosing cholangitis.BMC gastroenterology · 2024Article
- Transversal psoas muscle thickness measurement is associated with response and survival in patients with HCC undergoing immunotherapy.Hepatology communications · 2023Article
- A scoping review of the methods used in patients with liver cirrhosis to assess body composition and their nutritional findings.European journal of clinical nutrition · 2023Article
- Liver transplantation in the patient with physical frailty.Journal of hepatology · 2023Review
- Contributory roles of sarcopenia and myosteatosis in development of overt hepatic encephalopathy and mortality after transjugular intrahepatic portosystemic shunt.World journal of gastroenterology · 2023Article
- Osteosarcopenia in NAFLD/MAFLD: An Underappreciated Clinical Problem in Chronic Liver Disease.International journal of molecular sciences · 2023Review
- Prevalence and prognosis of Computed-Tomography defined sarcopenia in Tunisian cirrhotic patients.La Tunisie medicale · 2023Article
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11 authors at 2 institutions in 1 country.
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Abstract
BACKGROUND &
aimsLow muscle mass impacts on morbidity and mortality in cirrhosis. The skeletal-muscle index (SMI) is a well-validated tool to diagnose muscle wasting, but requires specialized radiologic software and expertise. Thus, we compared different Computed tomography (CT)-based evaluation methods for muscle wasting and their prognostic value in cirrhosis.
methodsConsecutive cirrhotic patients included in a prospective registry undergoing abdominal CT scans were analysed. SMI, transversal psoas muscle thickness (TPMT), total psoas volume (TPV) and paraspinal muscle index (PSMI) were measured. Sarcopenia was defined using SMI as a reference method by applying sex-specific cut-offs (males: <52.4 cm
resultsOne hundred and nine patients (71.6% male) of age 57 ± 11 years, MELD 16 (8-26) and alcoholic liver disease (63.3%) as the main aetiology were included. According to established SMI cut-offs, low muscle mass was present in 69 patients (63.3%) who also presented with higher MELD (17 vs 14 points; P = .025). The following optimal sex-specific cut-offs (men/women) for diagnosing low muscle mass were determined: TPMT: <10.7/ <7.8 mm/m, TPV: <194.9/ <99.2 cm
conclusionLow muscle mass was highly prevalent in our cohort of patients with cirrhosis. Gender-specific TPMT, SMI and PSMI cut-offs for low muscle mass can help identify patients with an increased risk for mortality. Importantly, only TPMT emerged as an independent risk factor for mortality in patients with cirrhosis.
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