ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2020
Trends in deceased donor liver enzymes prior to transplant: The impact on graft selection and outcomes.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Machine Perfusion in Liver Transplantation: A Systematic Review and Meta-Analysis.Visceral medicine · 2022Pooled it
- Expanding the donor pool: Outcomes of liver transplantation using grafts with ≥50% macrosteatosis.Journal of liver transplantation · 2026Article
- Standardized evaluation protocols for deceased and living liver donors: a practical framework for emerging liver transplant programs.Frontiers in transplantation · 2026Review
- Perspectives and Tools in Liver Graft Assessment: A Transformative Era in Liver Transplantation.Biomedicines · 2025Review
- Integrated transcriptomics and histopathology approach identifies a subset of rejected donor livers with potential suitability for transplantation.BMC genomics · 2024Article
- Impact of donor transaminases on liver transplant utilisation and unnecessary organ discard: national registry cohort study.Frontiers in transplantation · 2024Article
- Revisiting the "Weekend Effect" on Adult and Pediatric Liver and Kidney Offer Acceptance.Annals of transplantation · 2022Article
- Machine Perfusion for Extended Criteria Donor Livers: What Challenges Remain?Journal of clinical medicine · 2022Review
- Donor Evaluation Protocol for Live and Deceased Donors.Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
We sought to characterize the trend in alanine aminotransferase elevations prior to transplant and the impact on the pattern of enzyme elevations on organ utilization and graft function. We performed a retrospective cohort study of UNOS data on all deceased donors between 2007 and 2016. Serum alanine aminotransferase (ALT) was categorized into six study groups with peak ALT < 499, 500-749, 750-999, 1000-1999, 2000-2999, and >3000 IU/L. The change from peak ALT to terminal ALT prior to transplant was categorized as no change/increasing at time transplant, 0.1-9.9%, 10-24.9%, 25-49.9%, 50-74.9% and >75% change. In multivariable models evaluating liver utilization, the interaction between peak ALT and percent change in ALT was most pronounced at the highest peak ALT levels, where liver utilization varied markedly as a function of percentage drop from peak to terminal ALT. There was no increased risk of graft failure based on peak ALT. Markers of ischemic liver injury and recovery are significantly associated with liver utilization, yet among transplanted livers they were not associated with graft outcomes and may represent an area to expand the donor pool.
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Registered trials
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