Evidence map›Paper›PMID 31420758›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2020

Association of plasma trimethylamine-N-oxide levels with post-stroke cognitive impairment: a 1-year longitudinal study.

Chen Zhu, Guangzong Li, Zhiyu Lv, Jing Li, Xiangming Wang, Jie Kang, Cheng Zhan

Abstract read
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In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
38citing papers in PubMed, 5 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

38 citing papers in PubMed, 5 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  6. Article
  7. Blood-Based Biomarkers for Post-Stroke Cognitive Impairment.Current issues in molecular biology · 2026
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  16. Research progress in the relationship between gut microbiota metabolite trimethylamine N-oxide and ischemic stroke.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chen ZhuDepartment of Neurology, Central Hospital of Panzhihua City, No. 34 Yikang Street, Panzhihua, 617000, Sichuan Province, China.
Guangzong LiDepartment of Neurology, Central Hospital of Panzhihua City, No. 34 Yikang Street, Panzhihua, 617000, Sichuan Province, China.
Zhiyu LvDepartment of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou, 646000, Sichuan Province, China.
Jing LiDepartment of Clinical Laboratory, Central Hospital of Panzhihua City, Panzhihua, 617000, Sichuan Province, China.
Xiangming WangDepartment of Neurology, Central Hospital of Panzhihua City, No. 34 Yikang Street, Panzhihua, 617000, Sichuan Province, China.
Jie KangDepartment of Neurology, Central Hospital of Panzhihua City, No. 34 Yikang Street, Panzhihua, 617000, Sichuan Province, China.
Cheng ZhanDepartment of Neurology, Central Hospital of Panzhihua City, No. 34 Yikang Street, Panzhihua, 617000, Sichuan Province, China. zhancheng_neuro@126.com.ORCID http://orcid.org/0000-0001-6956-4005
Panzhihua Central Hospital · CNAffiliated Hospital of Southwest Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsPost-stroke cognitive impairment (PSCI) is a clinical condition arising from stroke and causes significant changes to memory, thinking, and behavior. Trimethylamine-N-oxide (TMAO), the metabolite produced by gut microbiota, has mechanistic relevance to atherosclerotic diseases. This study aimed to investigate whether an association existed between elevated plasma TMAO levels and PSCI.

methodsConsecutive patients with acute ischemic stroke were prospectively enrolled during Jan. 2017 to Dec. 2017. TMAO concentration was measured within 24 h after admission. PSCI was assessed using the Mini-Mental State Examination (MMSE) score after 1 year and defined as MMSE score ≤ 26. Binary logistic regression analysis was used to determine the contribution of TMAO level in the prediction of PSCI.

resultsOf the 256 patients studied (age, 67.1 ± 11.0 years; male, 54.3%), 86 (33.6%) patients were diagnosed as PSCI. The mean TMAO level was 5.6 ± 2.4 μM, with quartile level as follows: < 3.9 μM (first quartile), 3.9-5.1 μM (second quartile), 5.2-7.4 μM (third quartile), and > 7.4 μM (fourth quartile). After controlling for potential confounders, multivariable logistic analysis showed that higher level of plasma TMAO was an independent predictor for cognitive impairment in post-stroke patients (the quartile 1 was used as reference, the quartile 4 odds ratio, 3.304; 95% confidence intervals, 1.335-8.178; P = 0.010).

conclusionsThis study demonstrated that increasing plasma level of TMAO may be associated with PSCI.

Indexed as

AgedAged, 80 and overBiomarkersBrain IschemiaCognitive DysfunctionFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMethylaminesMiddle AgedProspective StudiesStrokeTime FactorsBiomarkersMethylaminestrimethyloxaminePost-stroke cognitive impairmentRisk factorsStrokeTrimethylamine-N-oxide

Identifiers

PMID31420758
OpenAlexW2968883940

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.