Evidence map›Paper›PMID 31420719›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2020

Neryl butyrate induces contractile effects on isolated preparations of rat aorta.

Emanuella Feitosa de Carvalho, Kalinne Kelly Lima Gadelha, Daniel Maia Nogueira de Oliveira, Karine Lima-Silva, Francisco José Batista-Lima, Teresinha Silva de Brito, Suliana Mesquita Paula, Moisés Tolentino Bento da Silva, Armênio Aguiar Dos Santos, Pedro Jorge Caldas Magalhães

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Emanuella Feitosa de CarvalhoDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Kalinne Kelly Lima GadelhaDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Daniel Maia Nogueira de OliveiraDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Karine Lima-SilvaDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Francisco José Batista-LimaDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Teresinha Silva de BritoDepartment of Health Sciences, Rural Federal University of the Semiarid, Mossoró, RN, Brazil.
Suliana Mesquita PaulaDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Moisés Tolentino Bento da SilvaDepartment of Physical Education, Federal University of Piauí, Teresina, PI, Brazil.
Armênio Aguiar Dos SantosDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil.
Pedro Jorge Caldas MagalhãesDepartment of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, CE, Brazil. pjcmagal@ufc.br.ORCID 0000-0002-9073-5750
Universidade Federal do Ceará · BRUniversidade Federal do Piauí · BRUniversidade Federal Rural do Semi-Árido · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neryl butyrate is a constituent of volatile oils obtained from aromatic plants. Aliphatic organic compound analogues chemically close to neryl butyrate possess vasodilator properties in rat aorta. To evaluate whether neryl butyrate has relaxing properties, this study tested its effects on isolated rat aorta. Unlike the analogues, neryl butyrate did not show relaxant profile in aortic rings precontracted with phenylephrine, but induced a contraction when it stimulated aortic rings under resting tonus. The contractile effect augmented in endothelium-denuded aortic rings. Treatment of endothelium-intact preparations with the nitric oxide synthase inhibitor L-NAME or the guanylyl cyclase inhibitor ODQ also augmented the contractile effect of neryl butyrate. Such phenomenon was absent in the presence of the cyclooxygenase inhibitor indomethacin. Contractile responses decreased in the presence of verapamil, a L-type Ca

Indexed as

Adrenergic alpha-AgonistsAmidesAnimalsAorta, ThoracicButyratesCalciumEstrenesHeart AtriaIn Vitro TechniquesMalePhenylephrinePhosphodiesterase InhibitorsProtein Kinase InhibitorsPyridinesPyrrolidinonesRats, Wistar1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dioneAdrenergic alpha-AgonistsAmidesButyratesCalciumEstrenesPhenylephrinePhosphodiesterase InhibitorsProtein Kinase InhibitorsPyridinesPyrrolidinonesVasoconstrictor AgentsY 27632Adrenergic receptorsMonoterpenesThoracic aortaVascular endothelium

Identifiers

PMID31420719
OpenAlexW2969174903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.