Evidence map›Paper›PMID 31420686›Full record

SynthesisNeuroradiology2019

Reorganization of the brain in spinal cord injury: a meta-analysis of functional MRI studies.

Wenzhao Wang, Wei Xie, Qianqian Zhang, Lei Liu, Jian Liu, Song Zhou, Jixue Shi, Jianan Chen, Bin Ning

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neuroradiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenzhao WangDepartment of Orthopedics, Shandong First Medical University/ West China Hospital, Sichuan University, Chengdu, Shandong/Sichuan, China.
Wei XieDepartment of Orthopedics, Shandong First Medical University/ West China Hospital, Sichuan University, Chengdu, Shandong/Sichuan, China.
Qianqian ZhangDepartment Obstetrics and Gynecology, The Second Affiliated Hospital of Shandong First Medical University, Taian, Shandong, China.
Lei LiuDepartment of Orthopedics, Shandong First Medical University/ West China Hospital, Sichuan University, Chengdu, Shandong/Sichuan, China.
Jian LiuDepartment Spinal Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Song ZhouDepartment of Orthopedics, Shandong First Medical University/ West China Hospital, Sichuan University, Chengdu, Shandong/Sichuan, China.
Jixue ShiDepartment of Orthopedics, Shandong First Medical University/ West China Hospital, Sichuan University, Chengdu, Shandong/Sichuan, China.
Jianan ChenDepartment Spinal Surgery, Jinan Central Hospital Affiliated to Shandong University, Jinan, Shandong, China.
Bin NingDepartment of Orthopedics, Shandong First Medical University/ West China Hospital, Sichuan University, Chengdu, Shandong/Sichuan, China. ningbin@sdu.edu.cn.ORCID http://orcid.org/0000-0002-7592-9485

Funding

National Natural Science Fund of China 81771346National Natural Science Fund of China 81874002Science and Technology Development Program of Taian City 201640576Shandong Medical and Health Science and Technology Development Programs 2016WS0618Technology Research and Development Program of Jinan City 201704133the Chinese Postdoctoral Science Foundation 2015T80725The Natural Science Funds of Shandong Province ZR2016HP41
6 · The paper itself

Abstract

purposeReorganization of the brain is considered the key mechanism of functional recovery in patients after spinal cord injury (SCI). This meta-analysis assessed abnormal brain activation in SCI patients to understand the pattern of reorganization in the brain after SCI.

methodsFunctional magnetic resonance imaging (fMRI) studies that compared SCI patients with controls and were published before August 30, 2018, were extracted from the PubMed, Web of Science, and EMBASE databases. Voxel-wise whole-brain meta-analysis and region-of-interest meta-analysis of group differences were separately performed. Then, meta-regression analysis was conducted with several clinical characteristics as regressors.

resultsSixteen studies that met the inclusion criteria were identified. Compared with control individuals, SCI patients showed increased activation in the sensorimotor cortex in both whole-brain and region-of-interest (ROI) analyses. In addition, whole-brain meta-analysis revealed increased activation in the cerebellum, and this increase was positively correlated with lesion level and injury severity.

conclusionOur results demonstrated that reorganization occurred mainly in the sensorimotor system of the brain after SCI, implying that brain functions involved in sensorimotor demands can still be preserved in this condition. These findings provide opportunities for future studies in terms of therapeutic strategies and prognosis assessment.

Indexed as

BrainBrain MappingHumansMagnetic Resonance ImagingRecovery of FunctionSpinal Cord InjuriesFunctional magnetic resonance imaging (fMRI)Meta-analysisNeuroimagingReorganizationSpinal cord injury (SCI)

Identifiers

PMID31420686

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.