ArticleThe international journal of neuropsychopharmacology2019
Hypothalamic Responses to Cocaine and Food Cues in Individuals with Cocaine Dependence.
Article in The international journal of neuropsychopharmacology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Meta-Analysis of Structural and Functional Brain Abnormalities in Cocaine Addiction.Frontiers in psychiatry · 2022Pooled it
- Assessing craving in cocaine and cocaine base paste users: validation of the Cocaine Craving Questionnaire-Brief in a Chilean sample.Addiction science & clinical practice · 2026Article
- Polygenic Risks for Depression and Neural Responses to Reward and Punishment in Young Adults.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- Cocaine Cues Used in Experimental Research: A Systematic Review.Brain sciences · 2025Review
- Cocaine self-administration attenuates brain glucose metabolism and functional connectivity in rats.PloS one · 2025Article
- Functional Networks of Reward and Punishment Processing and Their Molecular Profiles Predicting the Severity of Young Adult Drinking.Brain sciences · 2024Article
- Mapping the Neural Substrates of Cocaine Craving: A Systematic Review.Brain sciences · 2024Review
- Article
- Sex differences in externalizing and internalizing traits and ventral striatal responses to monetary loss.Journal of psychiatric research · 2023Article
- Endocannabinoid System Regulation in Female Rats with Recurrent Episodes of Binge Eating.International journal of molecular sciences · 2022Article
- Oxytocin and orexin systems bidirectionally regulate the ability of opioid cues to bias reward seeking.Translational psychiatry · 2022Article
- Loss and Frontal Striatal Reactivities Characterize Alcohol Use Severity and Rule-Breaking Behavior in Young Adult Drinkers.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2022Article
- Alcohol use severity and the neural correlates of the effects of sleep disturbance on sustained visual attention.Journal of psychiatric research · 2021Article
- Resting state hypothalamic and dorsomedial prefrontal cortical connectivity of the periaqueductal gray in cocaine addiction.Addiction biology · 2021Article
- Perceived friendship and binge drinking in young adults: A study of the Human Connectome Project data.Drug and alcohol dependence · 2021Article
- Midcingulate Cortical Activations Interrelate Chronic Craving and Physiological Responses to Negative Emotions in Cocaine Addiction.Biological psychiatry global open science · 2021Article
- Noradrenergic correlates of chronic cocaine craving: neuromelanin and functional brain imaging.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Cue-elicited functional connectivity of the periaqueductal gray and tonic cocaine craving.Drug and alcohol dependence · 2020Article
- Neural Responses to Reward in a Gambling Task: Sex Differences and Individual Variation in Reward-Driven Impulsivity.Cerebral cortex communications · 2020Article
- Sex Differences in Neural Responses to the Perception of Social Interactions.Frontiers in human neuroscience · 2020Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIndividuals with cocaine addiction are characterized by under-responsiveness to natural reinforcers. As part of the dopaminergic pathways, the hypothalamus supports motivated behaviors. Rodent studies suggested inter-related roles of the hypothalamus in regulating drug and food intake. However, few studies have investigated hypothalamic responses to drugs and food or related cues in humans.
methodsWe examined regional responses in 20 cocaine-dependent and 24 healthy control participants exposed to cocaine/food (cocaine dependent) and food (healthy control) vs neutral cues during functional magnetic resonance imaging. We examined the relationship between imaging findings and clinical variables and performed mediation analyses to examine the inter-relationships between cue-related activations, tonic cocaine craving, and recent cocaine use.
resultsAt a corrected threshold, cocaine-dependent participants demonstrated higher activation to cocaine than to food cues in the hypothalamus, inferior parietal cortex, and visual cortex. Cocaine-dependent participants as compared with healthy control participants also demonstrated higher hypothalamic activation to food cues. Further, the extent of these cue-induced hypothalamic activations was correlated with tonic craving, as assessed by the Cocaine Craving Questionnaire, and days of cocaine use in the prior month. In mediation analyses, hypothalamic activation to cocaine and food cues both completely mediated the relationship between the Cocaine Craving Questionnaire score and days of cocaine use in the past month.
conclusionsThe results were consistent with the proposition that the mechanisms of feeding and drug addiction are inter-linked in the hypothalamus and altered in cocaine addiction. The findings provide new evidence in support of hypothalamic dysfunction in cocaine addiction.
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