ArticleScientific reports2019
A novel thermostable D-amino acid oxidase of the thermophilic fungus Rasamsonia emersonii strain YA.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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6 citing papers in PubMed, 20 citations in OpenAlex.
- Identification of a novel D-amino acid oxidase and its application in deracemization of D, L-phosphinothricin.Bioprocess and biosystems engineering · 2025Article
- Modeling the role of charged residues in thermophilic proteins by rotamer and dynamic cross correlation analysis.Journal of molecular modeling · 2023Article
- Green Oxidation of Amines by a Novel Cold-Adapted Monoamine Oxidase MAO P3 from Psychrophilic FungiMolecules (Basel, Switzerland) · 2021Article
- A novel hyperthermophilic methylglyoxal synthase: molecular dynamic analysis on the regional fluctuations.Scientific reports · 2021Article
- X-ray structure analysis of a unique D-amino-acid oxidase from the thermophilic fungus Rasamsonia emersonii strain YA.Acta crystallographica. Section F, Structural biology communications · 2020Article
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5 authors at 2 institutions in 1 country.
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Abstract
D-Amino acid oxidase (DAAO) is a valuable flavoenzyme capable of being used in various practical applications, such as in determining D-amino acids and producing a material for semisynthetic cephalosporins, requiring higher thermal stability, higher catalytic activity, and broad substrate specificity. In this study, we isolated the thermophilic fungus Rasamsonia emersonii strain YA, which can grow on several D-amino acids as the sole nitrogen source, from a compost and characterized DAAO (ReDAAO) of the fungus. ReDAAO expressed in Escherichia coli exhibited significant oxidase activity against various neutral and basic D-amino acids, in particular hydrophobic D-amino acids. In addition, the enzyme also significantly acted on cephalosporin C, a starting material for semisynthetic antibiotics, and D-Glu, a general substrate for D-aspartate oxidase but not for DAAO, showing its unique and practically useful substrate specificity. The apparent k
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