Trial reportScientific reports2019
Analysis of the TCR Repertoire in HIV-Exposed but Uninfected Infants.
Trial report in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- The Effects of In Utero HIV and Antiretroviral Therapy Exposure on Infant T-Cell and Monocyte Activation, Function, and Regulation of Immune-Modulatory Pathways.Mediators of inflammation · 2026Article
- Impaired clinical, biological, and cytokine patterns in HIV-1 exposed uninfected newborns in Yaoundé: A comparative study of neonatal immune vulnerability.African journal of laboratory medicine · 2026Article
- KIR2DL1 gene is a surrogate marker of protection against infection-related hospitalization among HIV-1 unexposed versus exposed uninfected infants in Cameroon.BMC immunology · 2024Article
- Premature skewing of T cell receptor clonality and delayed memory expansion in HIV-exposed infants.Nature communications · 2024Article
- Triggered - does maternal COVID-19 program an exaggerated immune response in neonates?Pediatric research · 2024Article
- HIV-exposed uninfected infants' immune defects: From pathogen sensing, oxidative burst to antigens responses.iScience · 2023Review
- Lower academic performance among children with perinatal HIV exposure in Botswana.Journal of the International AIDS Society · 2023Article
- Disrupted memory T cell expansion in HIV-exposed uninfected infants is preceded by premature skewing of T cell receptor clonality.bioRxiv : the preprint server for biology · 2023Article
- Review
- Factors influencing maternal microchimerism throughout infancy and its impact on infant T cell immunity.The Journal of clinical investigation · 2022Article
- The importance of taking ART appropriately in children and adolescents with HIV-1 to reach the highest capacity of immune function later in life.Frontiers in immunology · 2022Article
- Comparative Study of Repertoire Classification Methods Reveals Data Efficiency ofFrontiers in immunology · 2022Article
- SARS-CoV2 Infection During Pregnancy Causes Persistent Immune Abnormalities in Women Without Affecting the Newborns.Frontiers in immunology · 2022Article
- Characteristics of the Gut Microbiome and Its Relationship With Peripheral CD4Frontiers in microbiology · 2022Article
- Impaired T helper cell responses in human immunodeficiency virus-exposed uninfected newborns.Immunity, inflammation and disease · 2021Article
- The legacy of maternal SARS-CoV-2 infection on the immunology of the neonate.Nature immunology · 2021Article
- Maternal T Cells in the Human Placental Villi Support an Allograft Response during Noninfectious Villitis.Journal of immunology (Baltimore, Md. : 1950) · 2020Article
- T Cell Repertoire During Ontogeny and Characteristics in Inflammatory Disorders in Adults and Childhood.Frontiers in immunology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
Maternal human immunodeficiency virus (HIV) infection has been shown to leave profound and lasting impacts on the HIV-exposed uninfected (HEU) infant, including increased mortality and morbidity, immunological changes, and developmental delays compared to their HIV-unexposed (HU) counterparts. Exposure to HIV or antiretroviral therapy may influence immune development, which could increase morbidity and mortality. However, a direct link between the increased mortality and morbidity and the infant's immune system has not been identified. To provide a global picture of the neonatal T cell repertoire in HEU versus HU infants, the diversity of the T cell receptor beta chain (TRB) expressed in cord blood samples from HEU infants was determined using next-generation sequencing and compared to healthy (HU) infants collected from the same community. While the TRB repertoire of HU infants was broadly diverse, in line with the expected idea of a naïve T cell repertoire, samples of HEU infants showed a significantly reduced TRB diversity. This study is the first to demonstrate differences in TRB diversity between HEU and HU cord blood samples and provides evidence that maternal HIV, in the absence of transmission, influences the adaptive immune system of the unborn child.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.