ArticleScientific reports2019
Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 36 citations in OpenAlex.
- Cardiovascular Organoids With Adjustable Endothelial Composition via SOX17-Engineered hPSCs.Biotechnology and bioengineering · 2026Article
- Loss of cold shock domain-containing protein E1 (CSDE1) function enhances mRNA stability of interleukin-6 and promotes malignant transformation in endometrial cancer cells.Cell communication and signaling : CCS · 2026Article
- Molecular and Functional Divergence of Zebrafish Sox Paralogs Controlling Endoderm Formation and Left-Right Patterning.Genome biology and evolution · 2025Article
- Cardiac Development, Cellular Composition and Function: From Regulatory Mechanisms to Applications.Cells · 2025Review
- A spatiotemporal atlas of mouse gastrulation and early organogenesis to explore axial patterning and project in vitro models onto in vivo space.Cell reports · 2025Article
- SOX17 in pulmonary arterial hypertension: from development to clinical phenotype.European respiratory review : an official journal of the European Respiratory Society · 2025Review
- TRIAGE: an R package for regulatory gene analysis.Briefings in bioinformatics · 2025Article
- The molecular mechanisms of cardiac development and related diseases.Signal transduction and targeted therapy · 2024Review
- Sox17 and Other SoxF-Family Proteins Play Key Roles in the Hematopoiesis of Mouse Embryos.Cells · 2024Review
- CHD4 and SMYD1 repress common transcriptional programs in the developing heart.Development (Cambridge, England) · 2024Article
- SOX17/ETV2 improves the direct reprogramming of adult fibroblasts to endothelial cells.Cell reports methods · 2024Article
- Seven Additional Patients withGenes · 2023Review
- Sox7-positive endothelial progenitors establish coronary arteries and govern ventricular compaction.EMBO reports · 2023Article
- Sox17 mediates adult arterial endothelial cell adaptation to hemodynamics.Biomaterials · 2023Article
- Nkx2.5: a crucial regulator of cardiac development, regeneration and diseases.Frontiers in cardiovascular medicine · 2023Review
- Article
- Platr4 is an early embryonic lncRNA that exerts its function downstream on cardiogenic mesodermal lineage commitment.Developmental cell · 2022Article
- Differential regulation of alternate promoter regions iniScience · 2022Article
- Molecular genetics of pulmonary hypertension in children.Current opinion in genetics & development · 2022Review
- A SOX17-PDGFB signaling axis regulates aortic root development.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 10 institutions in 5 countries.
Rie SabaCentres for Microvascular Research and for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Keiko KitajimaDepartment of Developmental Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Lucille RainbowCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
Silvia EngertInstitute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.
Mami UemuraDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.
Hidekazu IshidaCentres for Microvascular Research and for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Ioannis KokkinopoulosCentres for Microvascular Research and for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Yasunori ShintaniCentres for Microvascular Research and for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Shigeru MiyagawaDepartment of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Yoshiakira KanaiDepartment of Veterinary Anatomy, The University of Tokyo, Tokyo, Japan.
Masami Kanai-AzumaDepartment of Experimental Animal Models for Human Disease, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.
Peter KoopmanDivision of Molecular Genetics and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Australia.
Chikara MenoDepartment of Developmental Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
John KennyCentre for Genomic Research, Institute of Integrative Biology, University of Liverpool, Liverpool, UK.
Heiko LickertInstitute of Diabetes and Regeneration Research, Helmholtz Zentrum München, Neuherberg, Germany.
Yumiko SagaDivision of Mammalian Development, Genetic Strains Research Center, National Institute of Genetics, Shizuoka, Japan.
Ken SuzukiCentres for Microvascular Research and for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Yoshiki SawaDepartment of Cardiovascular Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Kenta YashiroCentres for Microvascular Research and for Endocrinology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. kyashiro@koto.kpu-m.ac.jp.
Osaka University · JPQueen Mary University of London · GBHelmholtz Zentrum München · DEKyushu University · JPTokyo Medical and Dental University · JPUniversity of Liverpool · GBNational Institute of Genetics · JPThe University of Tokyo · JPUniversity of Queensland · AUWilliam Harvey Research Institute · GB
Funding
British Heart Foundation PG/11/102/29213Medical Research Council G0900105Medical Research Council MR/J007625/1
Abstract
The endocardium is the endothelial component of the vertebrate heart and plays a key role in heart development. Where, when, and how the endocardium segregates during embryogenesis have remained largely unknown, however. We now show that Nkx2-5
Indexed as
Cell DifferentiationGene Expression Regulation, DevelopmentalSignal TransductionAnimalsEmbryo, MammalianEndocardiumHMGB ProteinsMesodermMiceMice, TransgenicReceptors, NotchSOXF Transcription FactorsStem CellsHMGB ProteinsReceptors, NotchSox17 protein, mouseSOXF Transcription Factors
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.