Evidence map›Paper›PMID 31420570›Full record

Observational studyScientific reports2019

HBcAb seropositivity is correlated with poor HIV viremia control in an Italian cohort of HIV/HBV-coinfected patients on first-line therapy.

Vincenzo Malagnino, Carlotta Cerva, Gaetano Maffongelli, Elisabetta Teti, Luca Foroghi Biland, Novella Cesta, Margherita De Masi, Christof Stingone, Daniele Armenia, Valentina Svicher and 3 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Vincenzo MalagninoClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.
Carlotta CervaClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.
Gaetano MaffongelliDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Elisabetta TetiDepartment of Systems Medicine, Tor Vergata University of Rome, Rome, Italy.
Luca Foroghi BilandClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.ORCID http://orcid.org/0000-0001-5283-1250
Novella CestaClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.
Margherita De MasiClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.
Christof StingoneClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.
Daniele ArmeniaDepartment of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
Valentina SvicherDepartment of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
Romina SalpiniDepartment of Experimental Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy.
Massimo AndreoniClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy.
Loredana SarmatiClinic of Infectious Diseases, Policlinico Tor Vergata, Rome, Italy. sarmati@med.uniroma2.it.ORCID http://orcid.org/0000-0003-1452-0333
University of Rome Tor Vergata · ITPoliclinico Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The morbidity and mortality rates of human immunodeficiency virus (HIV)-hepatitis B virus (HBV) coinfection are higher than that of either infection alone. Outcomes and the virological response to antiretrovirals (combination antiretroviral therapy, cART) were explored in HIV/HBV subjects in a cohort of Italian patients treated with cART. A single-center retrospective analysis of patients enrolled from January 2007 to June 2018 was conducted by grouping patients by HBV status and recording baseline viro-immunological features, the history of virological failure, the efficacy of cART in achieving HIV viral undetectability, viral blip detection and viral rebound on follow up. Among 231 enrolled patients, 10 (4.3%) were HBV surface (s) antigen (HBsAg)-positive, 85 (36.8%) were positive for antibodies to HBV c antigen (HBcAb) and with or without antibodies to HBV s antigen (HBsAb), and 136 were (58.9%) HBV-negative. At baseline, HBcAb/HBsAb

Indexed as

AdultAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-LymphocytesCoinfectionDNA, ViralFemaleHepatitis B AntibodiesHepatitis B, ChronicHepatitis B Core AntigensHepatitis B Surface AntigensHepatitis B virusHIV-1HIV AntibodiesHIV InfectionsAnti-HIV AgentsDNA, ViralHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B Surface AntigensHIV Antibodies

Identifiers

PMID31420570
PMCPMC6697726
OpenAlexW2968527855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.